High-order multiple pregnancy: is it a matter of inaction or a consequence of practice patterns? [PDF]
, 2003 Zev Rosenwaks, Pak H. Chung
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The relationship of regret and the negative impact of life events on life satisfaction : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]
, 2003 The present study provided a comparative, descriptive account, across age and gender, of the content and incidence of regret along ten domains; namely, career, finance, leisure, health, family relationships, relationships with friends, intimate ...
Naidu, Siddartha
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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The Brazilian Government's Inaction Policy in the face of the COVID-19 pandemic
GIGAPP Estudios Working Papers, 2020 This article aim show the inaction in public policy to combat COVID-19 in Brazil, making the country the second in the number of cases and second in the number of deaths in the world.
Marco Teixeira, Dr. +3 more
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
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An Investigation of Inaction in Samuel Beckett's Waiting for Godot: A Literary Darwinian Perspective [PDF]
, 2016 Bahareh Merhabi, Amrollah Abjadian
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When enough countries lead by example, they create a tipping point for climate agreements [PDF]
, 2016 But uncertainties risk reverting the game back to a 'prisoner's dilemma' and inaction, write İriş and ...
İriş, Doruk, Tavoni, Alessandro
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
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