Results 121 to 130 of about 189,682 (288)

Cost saving analysis of prediabetes intervention modalities in comparison with inaction using Markov state transition model—A multiregional case study

open access: yesJournal of Diabetes
Background Prediabetes management is a priority for policymakers globally, to avoid/delay type 2 diabetes (T2D) and reduce severe, costly health consequences.
Hussain Abdulrahman Al‐Omar   +6 more
doaj   +1 more source

Ecological Distribution, Agricultural Trade Liberalization, and In Situ Genetic Diversity [PDF]

open access: yes
Genetic diversity in crop plants is crucial for long-term world food security. This diversity is sustained in the field primarily by poor farmers in developing countries, who receive no compensation for providing this external benefit to humankind.
James Boyce
core  

A Holistic Vision of the Socio-Legal Terrain [PDF]

open access: yes, 2008
Tamanaha discusses Marc Galanter\u27s holistic vision of the socio-legal terrain. Galanter\u27s socio-legal vision has two central overlapping foci, and he always keeps an eye on each and on their interaction.
Tamanaha, Brian Z.
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The inspiration of Lao Tzu’s philosophical thoughts to the entrepreneurial spirit of mediation and production

open access: yesTrans/Form/Ação
This article adopts a combination of literature review and theoretical analysis to explore the application value of Laozi’s management philosophy in contemporary enterprises, and based on this, construct entrepreneurial spirit and corporate culture.
Yixuan Shang
doaj   +1 more source

Consistent Vegetarianism and the Suffering of Wild Animals [PDF]

open access: yes, 2016
Ethical consequentialist vegetarians believe that farmed animals have lives that are worse than non-existence. In this paper, I sketch out an argument that wild animals have worse lives than farmed animals, and that consistent vegetarians should ...
Sittler-Adamczewski, Thomas M.
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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