Results 41 to 50 of about 30,087 (293)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Defining meanings by grammatical behaviour. The case of English verbs of inaction [PDF]
, 2018 This article deals with the definition of the meanings of verbs of inaction in English. The analysis is carried out within the framework of verbal classes and alternations and the theory of Role and Reference Grammar.
Ojanguren López, Ana Elvira [0000-0001-5356-7391] +1 more
core +1 more source
Why the Iranian Parliament has not adopted public participation tools in the legislative process? [PDF]
Public Administration and PolicyPurposeThis study investigates the critical question of why the Iranian Parliament has not adopted and institutionalizing established mechanisms for public participation in its legislative process.Design/methodology/approachEmploying a qualitative ...
Hassan Danaeefard +4 more
doaj +1 more source
Climate Change Inaction and Post-Reality
Philosophies, 2021 Blame for climate change inaction is rarely directed at a fundamental cause, the excessive complexity of society. It has given rise to post-truth, which has been largely reduced to unflattering stereotypes of the public, and post-trust, by which the ...
Philip J. Wilson
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Moving into View: Enacting Virtual Reality
MediaTropes, 2016 How do we perceive virtual reality? This simple question takes the reader on a journey into the physiology of perception, following cybernetic models that regard spatial perception as an activity that presupposes bodily motion.
Lasse Scherffig
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source