Results 171 to 180 of about 2,032,731 (300)

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Microplastic-associated gut microbial profile and antibiotic resistance in preschool children: a multicentre cross-sectional study in China. [PDF]

EBioMedicine
Liu X, Cai H, Zhao L, Ke D, Xu X, Li J, Yu J, Shen Y, Zhu L, Jin Y, Zhang M, Liu S, Du J, Zheng J, Dong R.   +14 more
europepmc   +1 more source

Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

EMBO Journal, 1997
H. Fujii, Takashi Sato, Sinya Kaneko, O. Gotoh, Y. Fujii‐Kuriyama, Kanju Osawa, S. Kato, H. Hamada   +7 more
semanticscholar   +1 more source

Photochemical Fuel Carrier Molecules for Robotic Embodied Energy

Advanced Materials, EarlyView.
We designed a novel fuel carrier photoresponsive molecule for on‐demand energy storage and release. Carrier molecules undergo bond scission under UV light to release chemical fuel and locally generate propulsive Marangoni flows. We demonstrate this photochemical embodied energy strategy in small‐scale robots and active matter systems, enabling ...
Chuqi Huang, Songah Jeong, Ji Woo Kim, Kanyarat Mantala, Zenghao Zhang, Hyungwoo Kim, Abdon Pena‐Francesch   +6 more
wiley   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

Network Hypoactivity in ALG13-CDG: Disrupted Developmental Pathways and E/I Imbalance as Early Drivers of Neurological Features in CDG. [PDF]

Cells
Shah R, Budhhraja R, Radenkovic S, Preston G, King AT, Sabry S, Bleukx C, Shammas I, Young L, Chandran J, Byeon SK, Hrstka R, Smith DY, Staff NP, Drake R, Sloan SA, Pandey A, Morava E, Kozicz T.   +18 more
europepmc   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Intratumoral <i>Fusobacterium nucleatum</i> metabolizes chemotherapy before it reaches cancer cells. [PDF]

Ann Med Surg (Lond)
Mehmood MS, Qasim Z, Rauf S, Danaf N.
europepmc   +1 more source

Enabling Real‐Time, Non‐Ionizing 3D Imaging of Implantable Magnetic Cements Using Magnetic Particle Imaging

Advanced Materials Interfaces, EarlyView.
This study reports the first implantable resin cement capable of orientation‐sensitive Magnetic Particle Imaging (MPI). By coating the cement with an ultrathin iron film, the authors achieve a strong, angle‐dependent MPI signal that enables non‐ionizing, real‐time tracking of both implant position and orientation, opening new possibilities for safe ...
Gabriel C. Pinto, João M. Costa, Simão P. Fernandes, Gabriela F. Resende, Eduardo T. C. Coimbra, Patrick Vogel, Mariana B. Oliveira, Marco Giardiello, Ricardo M. Silva, Armando A.C.S. Lourenço, Nuno J. O. Silva   +10 more
wiley   +1 more source

Bioelectrochemical detection of viable but non-culturable bacterial cells on screen-printed carbon electrodes. [PDF]

Biofilm
Otemoye OT, Nawab S, Zhong F, Liu J, Mattedi A, Debiagi P, Teng-Hern Tan L, Hardie KR, Xu Z, Marsili E.   +9 more
europepmc   +1 more source