Results 41 to 50 of about 3,072 (218)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

[Inappropriate ADH secretion syndrome].

Anales de medicina interna (Madrid, Spain : 1984), 1996
Six patients are with inappropriate secretion of antidiuretic hormone syndrome are reported (two with bacterial acute meningitis, two with bacterial pneumonia, one with oat cell lung carcinoma, other with mediterranean fever boutonneuse) and the clinical manifestations were: mind changes (four cases) nausea-vomiting (two cases) and inappetence (six ...
A, Rodríguez Cuartero, F, González Martínez   +1 more
openaire   +1 more source

Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 Cascade

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Extracellular hyperosmolality extracts water from the catalytic center of WNK1 increasing the kinase activity. WNK1 phosphorylates and activates OSR1/SPAK leading to increases in Kv3.1 activity. Enhanced Kv3.1 activity accelerates repolarization, increasing afterhyperpolarization (AHP) and/or shortening AP width to increase action potential firing ...
Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long Huang   +5 more
wiley   +1 more source

Overcorrection of severe hyponatremia, osmotic demyelination syndrome, and mortality: insights from two Brazilian centers [PDF]

Brazilian Journal of Nephrology
Introduction: Severe hyponatremia (sodium ≤ 120 mmol/L) poses significant clinical risks, including encephalopathy and seizures, but inadvertent rapid correction may cause osmotic demyelination syndrome (ODS). Current guidelines recommend limiting sodium
Lívia de Azevêdo Cerqueira Reis, Maria Gabriela Motta Guimarães, Ananda Pires Bastos, Dyonatas Rodrigues da Mata, Daniel Henrique Lins e Silva, Paulo Novis Rocha   +5 more
doaj   +1 more source

Efficacy and Safety of Orforglipron in Obese Adults With or Without Diabetes: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 8, Issue 6, November 2025.
This systematic review and meta‐analysis of 5 randomised controlled trials (4410 participants) demonstrates that orforglipron produces dose‐dependent reductions in HbA1c, BMI, body weight, and waist circumference in obese adults. Higher doses (24–45 mg) show greater efficacy, supporting orforglipron's promising role in managing obesity and improving ...
Ravi Kumar Pandey, Mahnoor Jan, Aqsa Mohammad, Khawaja Arham Jawaid, Mawra Naveed, Muhammad Ali Abid, Abdullah Bin Amir, Shafique Ahmed, Muhammad Safiullah, Muhammad Imaz Bhatti, Sana Iftikhar, Muhammad Nabeel Saddique, Widyan Alfalh, Rihab Mohammed bin Omar, Husam Abu Dawood   +14 more
wiley   +1 more source

The prevalence and risk factors of the Syndrome of Inappropriate Anti-Diuretic Hormone secretion (SIADH) following spinal surgery

Journal of Research in Medical Sciences, 2008
<ul> <li><strong>BACKGROUND</strong>: The Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) secretion is the most common etiology of normovolemic hyponatremia, which occurs following non-physiologic release of antidiuretic ...
Bahram Mobini, Ebrahim Ameri, Hamid Behtash, Behshad Bouzari, Payam Kabiri   +4 more
doaj  

Recurrent Symptomatic Hyponatremia Revealing a Late Diagnosis of Sheehan Syndrome and Effectively Treated With Levothyroxine: A Case Report and Brief Review of Literature

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT In women with a history of postpartum hemorrhage presenting with chronic symptoms such as hyponatremia, amenorrhea, weight loss, or cold intolerance, suspect Sheehan's syndrome. Early diagnosis and prompt hormonal replacement therapy are essential for reversing complications and improving quality of life.
Hayatu Awel Abdela, Germen Temam Abdulmalik, Numeri Husein Kimo, Kumel Nur Muktar, Rebi Ali Oumer, Tamirat Godebo Woyimo   +5 more
wiley   +1 more source

New Onset SIADH Masquerading Disease Progression during Treatment of Esthesioneuroblastoma

Clinical Pediatric Hematology-Oncology
Esthesioneuroblastoma (ENB) is a slow growing malignant tumour of olfactory neuro-epithelium that is locally aggressive with a tendency to recur years later. Infrequently, it can be associated with paraneoplastic syndrome.
Aashita, Vikas Yadav, Rajiv Sharma, Pragyat Thakur   +3 more
doaj   +1 more source

Anti-Aquaporin-4 Antibody-Positive Neuromyelitis Optica Presenting with Syndrome of Inappropriate Antidiuretic Hormone Secretion as an Initial Manifestation

Case Reports in Neurology, 2011
The distribution of neuromyelitis optica (NMO)-characteristic brain lesions corresponds to sites of high aquaporin-4 (AQP4) expression, and the brainstem and hypothalamus lesions that express high levels of AQP4 protein are relatively characteristic of ...
H. Nakajima, Y. Fujiki, T. Ito, H. Kitaoka, T. Takahashi   +4 more
doaj   +1 more source