Results 91 to 100 of about 26,855 (306)

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

ORTHOTOPIC LIVER TRANSPLANTATION FOR WILSON'S DISEASE [PDF]

, 1971
An 11-year-old boy with terminal hepatic failure due to Wilson's disease was treated 18 months ago with orthotopic liver transplantation. Postoperatively, there has been evidence of clearance of body copper stores but without accumulation of copper in ...
Dubois, RS, Giles, G, Halgrimson, CG, Lilly, J, Martineau, G, Rodgerson, DO, Scheinberg, IH, Shroter, G, Starzl, TE, Sternlieb, I   +9 more
core   +1 more source

The spread of non‐native species

Biological Reviews, EarlyView.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock, Ali Serhan Tarkan, Irene Martín‐Forés, Stelios Katsanevakis, Ronaldo Sousa, Ismael Soto, Andy J. Green, Antonín Kouba, Teun Everts, Victoria Dominguez Almela, Nadège Belouard, Cang Hui, Jamie Bojko, Victor Deklerck, Margaux Boeraeve, Franz Essl, J. Robert Britton   +16 more
wiley   +1 more source

Application of high-resolution mass spectrometry profiling towards the diagnosis and acute management of maple syrup urine disease

Molecular Genetics and Metabolism Reports
The current approach for investigating patients with suspected inborn errors of metabolism (IEMs) involves traditional targeted biochemical assays such as amino/organic acid analyses.
Rafael Garrett, Sara Pickett, Melinda J. Peters, Khadija Belhassan, Adam S. Ptolemy, Roy W.A. Peake   +5 more
doaj   +1 more source

Biochemistry and Molecular Biology PBL Cases

MedEdPORTAL, 2006
This resource is a collection of six problem-based learning (PBL) cases suitable for a biochemistry and molecular biology course taken by first- or second-year medical students.
Marshall Anderson
doaj   +1 more source

Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls [PDF]

, 2020
Michiel Bongaerts, Ramon Bonte, Serwet Demirdas, Ed H. Jacobs, Esmée Oussoren, Ans T. van der Ploeg, Margreet A.E.M. Wagenmakers, Robert M.W. Hofstra, Henk J. Blom, Marcel J.T. Reinders, George J. G. Ruijter   +10 more
openalex   +1 more source

Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates. We evaluated the safety and efficacy of lacosamide for neonatal seizures. Methods This 10‐center, retrospective study of neonates with seizures
Alexandra Santana Almansa, Jessica R. Landers, Nicholas S. Abend, Giulia M. Benedetti, Catherine J. Chu, Andrew T. Knox, Shavonne Massey, Steffany Moen, Andrea C. Pardo, Arnold Sansevere, Renée A. Shellhaas, Cameron Thomas, Tammy Tsuchida, Sonya Wang, Bo Zhang, Janet S. Soul   +15 more
wiley   +1 more source

Predicting metabolic biomarkers of human inborn errors of metabolism

Molecular Systems Biology, 2009
Early diagnosis of inborn errors of metabolism is commonly performed through biofluid metabolomics, which detects specific metabolic biomarkers whose concentration is altered due to genomic mutations.
Tomer Shlomi, Moran N Cabili, Eytan Ruppin   +2 more
doaj   +1 more source

Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Autism spectrum disorder (ASD) affects 1 in 36 individuals in the United States and is characterized by impaired social communication and restrictive/repetitive behaviors. Individuals with tuberous sclerosis complex (TSC) have a high incidence of ASD (40%) and exhibit congenital brain lesions (tubers), offering a unique lesion‐based ...
Wendy Xiao Herman, Gillian N. Miller, Mustafa Sahin, Jurriaan M. Peters, Simon K. Warfield, Darcy A. Krueger, E. Martina Bebin, Hope Northrup, Joyce Y. Wu, Michael D. Fox, Alexander L. Cohen   +10 more
wiley   +1 more source

Food or medicine? A European regulatory perspective on nutritional therapy products to treat inborn errors of metabolism [PDF]

, 2023
Nina N. Stolwijk, Annet M. Bosch, Natalja Bouwhuis, Johannes Häberle, Clara van Karnebeek, Francjan J. van Spronsen, Mirjam Langeveld, Carla E. M. Hollak   +7 more
openalex   +1 more source