Results 131 to 140 of about 36,711 (394)

Correction of an inborn error of metabolism by intraportal hepatocyte transplantation in a dog model.

open access: yesTransplantation, 1996
The aims of this study were (1) to assess portal hemodynamics during intraportal hepatocyte transplantation (HTX) in dogs, (2) to evaluate a new method for the detection of transplanted hepatocytes using 5-bromo-2'-deoxyuridine (BrdU) incorporation, and (
J. M. Kocken   +6 more
semanticscholar   +1 more source

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

open access: yesiMeta, EarlyView.
By integrating multi‐level and multi‐omics analyses, we identify 3,4‐dihydroxyphenylacetic acid (DHPAA), a gut microbiota‐derived degradation product of dietary flavonoids, as a key bioactive end‐product responsible for the beneficial effects against polycystic ovary syndrome (PCOS).
Pan Li   +22 more
wiley   +1 more source

Intralitter Variability Influences the Developmental Impact of Valproic Acid Exposure in CD‐1 Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug that causes teratogenic effects, including neural tube defects (NTDs), when taken during pregnancy. Although animal models are widely used to study VPA teratogenicity, most rely on litter means, which overlook variability within the litter.
Lauren T. L. Brown   +3 more
wiley   +1 more source

Congenital biotinidase deficiency – MRI findings in two cases

open access: yesIndian Journal of Radiology and Imaging, 2019
Congenital biotinidase deficiency is a rare inborn error of metabolism that most commonly presents in infantile age group. Diffusion changes on magnetic resonance imaging (MRI) are sparsely described in the literature.
Rahul S Ranjan   +3 more
doaj   +1 more source

Saliva as a TDM matrix and its application in the model‐informed precision dosing

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu   +9 more
wiley   +1 more source

A case report of a patient with mucopolysaccharidosis type II

open access: yesRevista Médica del Hospital General de México, 2017
Mucopolysaccharidosis type II (MPS II) or Hunter syndrome is an inborn error of metabolism due to lysosomal accumulation, with a recessive inheritance pattern linked to the X chromosome.
M.R. Rivera Vega   +3 more
doaj   +1 more source

Research progress on renal calculus associate with inborn error of metabolism. [PDF]

open access: yesZhejiang Da Xue Xue Bao Yi Xue Ban, 2023
Song Y, Zhao C, Li D.
europepmc   +1 more source

Interhospital variation in the management of Brief Resolved Unexplained Events (BRUE) in infants: A Canadian multicenter cohort study

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Background Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher‐risk category, leaving management decisions to individual clinicians and contributing to variation in care.
Nassr Nama   +18 more
wiley   +1 more source

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