Results 61 to 70 of about 2,741,348 (370)

Materials Advances in Devices for Heart Disease Interventions

Advanced Materials, EarlyView.
This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra, Lauryn Srethbhakdi, James Davies, Chi Cong Nguyen, Phuoc Thien Phan, Zachary Och, Aditya Ashok, Khoon S. Lim, Hoang‐Phuong Phan, Thanh Nho Do, Nigel H. Lovell, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

Neonatal Seizures: When to Consider and How to Investigate for an Inborn Error of Metabolism

Proceedings of Singapore Healthcare, 2010
Seizures occur more frequently in the neonatal period than in the remainder of childhood. Neonatal seizures can have different aetiologies. Inborn errors of metabolism are rare causes of seizures in the newborn.
Derrick Wei Shih Chan B Med Sci, MRCPCH (UK), Ee Shien Tan MBBS, MRCPCH (UK), Maureen Anne Cleary MD, MRCP (UK)   +2 more
doaj   +1 more source

Global organization of metabolic fluxes in the bacterium, Escherichia coli [PDF]

Nature 427, 839-843 (2004), 2004
Cellular metabolism, the integrated interconversion of thousands of metabolic substrates through enzyme-catalyzed biochemical reactions, is the most investigated complex intercellular web of molecular interactions. While the topological organization of individual reactions into metabolic networks is increasingly well understood, the principles ...
arxiv   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT An illustration of the importance of manual data review for identifying rare intronic variants adjacent to homopolymers is presented here. A 14‐year‐old male with Niemann‐Pick Type C disease confirmed biochemically was only found to have a heterozygous pathogenic variant by molecular analysis. A manual review of the Next Generation Sequencing (
Caroline Gully Brown, Matthew Bower, Matthew Schomaker, Jessica Goldstein, Jeanine Jarnes, Chester B. Whitley, Nishitha R. Pillai   +6 more
wiley   +1 more source

Leukotriene C4-Synthesis Deficiency

Pediatric Neurology Briefs, 1998
A leukotriene C4-synthesis deficiency, a new inborn error of eicosanoid metabolism characterized by hypotonia, microcephaly, failure to thrive, and retarded development, is described in an infant who died aged 6 months after a rapidly progressive course ...
J Gordon Millichap
doaj   +1 more source

Propionic acidemia presenting as encephalopathy, hyper-ammonemia, recurrent pulmonary hemorrhage: A case report

Journal of Pediatric Critical Care, 2020
The metabolic crisis due to inborn error of metabolism can present as an isolated entity or along with the underlying sepsis at any age in children. Here, we present 14 months old boy born of third-degree consanguinity, apparently healthy in the past ...
Ramaning Loni, Sachin Tapal, B Anita, Mahesh Kamale, LaxmanLaxman H Bidari   +4 more
doaj   +1 more source

INBORN ERRORS OF METABOLISM AND METABOLIC WORK-UP IN AUTISM SPECTRUM DISORDERS

Slovenska pediatrija, 2021
Autism spectrum disorders are complex developmental dis-orders characterised by disturbances in social interactions, verbal and non-verbal communication and imagination.
Anja Krivec Penič, Živa Prijatelj, Manca Ločičnik, Mojca Žerjav Tanšek   +3 more
doaj   +1 more source