Results 191 to 200 of about 53,000 (243)

The practice and promise of temporal genomics for measuring evolutionary responses to global change

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Understanding the evolutionary consequences of anthropogenic change is imperative for estimating long‐term species resilience. While contemporary genomic data can provide us with important insights into recent demographic histories, investigating past change using present genomic data alone has limitations.
René D. Clark, Katrina A. Catalano, Kyra S. Fitz, Eric Garcia, Kyle E. Jaynes, Brendan N. Reid, Allyson Sawkins, Anthony A. Snead, John C. Whalen, Malin L. Pinsky   +9 more
wiley   +1 more source

Easy‐to‐use R functions to separate reduced‐representation genomic datasets into sex‐linked and autosomal loci, and conduct sex assignment

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Identifying sex‐linked markers in genomic datasets is important because their presence in supposedly neutral autosomal datasets can result in incorrect estimates of genetic diversity, population structure and parentage. However, detecting sex‐linked loci can be challenging, and available scripts neglect some categories of sex‐linked variation.
Diana A. Robledo‐Ruiz, Lana Austin, J. Nevil Amos, Jesús Castrejón‐Figueroa, Daniel K. P. Harley, Michael J. L. Magrath, Paul Sunnucks, Alexandra Pavlova   +7 more
wiley   +1 more source

The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

Aging Cell, EarlyView.
The effects of the mitochondria‐targeted peptide therapeutic elamipretide on age‐related muscle function were compared with its effects on molecular biomarkers of aging. It was found that elamipretide treatment partially reverses age‐related cardiac dysfunction and skeletal muscle weakness in mice without significantly affecting muscle epigenetic or ...
Wayne Mitchell, Gavin Pharaoh, Alexander Tyshkovskiy, Matthew Campbell, David J. Marcinek, Vadim N. Gladyshev   +5 more
wiley   +1 more source

On Technics and Technology as a Modification of the Death Drive

Constellations, EarlyView.
Lachlan Ross
wiley   +1 more source

Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black

Aging Cell, EarlyView.
While the etiology of race differences in mobility is multifactorial, our data indicate that muscle mitochondrial respiration and cardiorespiratory fitness may contribute to the slower walking speed of individuals who identify as Black compared to White.
Paul M. Coen, Fanchao Yi, Li‐Yung Lui, Giovanna Distefano, Sofhia V. Ramos, Bret H. Goodpaster, Peggy M. Cawthon, Russell T. Hepple, Stephen B. Kritchevsky, Steven R. Cummings, Gregory J. Tranah, Anne B. Newman, James P. DeLany   +12 more
wiley   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Ecological Realism Accelerates Epigenetic Aging in Mice

Aging Cell, EarlyView.
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory‐reared and “re‐wilded” C57BL/6J mice, we reveal accelerated, genomic region‐dependent epigenetic aging in the liver under naturalistic field conditions, highlighting
Matthew N. Zipple, Ivan Zhao, Daniel Chang Kuo, Sol Moe Lee, Michael J. Sheehan, Wanding Zhou   +5 more
wiley   +1 more source

Investigating Chromosomal Radiosensitivity in Inborn Errors of Immunity: Insights from DNA Repair Disorders and Beyond. [PDF]

J Clin Immunol
Beyls E, Duthoo E, Backers L, Claes K, RAPID Clinicians, De Bruyne M, Pottie L, Bordon V, Bonroy C, Tavernier SJ, Claes KBM, Vral A, Baeyens A, Haerynck F.   +13 more
europepmc   +1 more source

Spectrum analysis of inborn errors of metabolism for expanded newborn screening in Xinjiang, China. [PDF]

PeerJ
Zhu J, Han L, Yang P, Feng Z, Xue S.
europepmc   +1 more source

Clinical decision instruments for predicting mortality in patients with cirrhosis seeking emergency department care

Academic Emergency Medicine, EarlyView.
Abstract Objective Clinical decision instruments (CDIs) could be useful to aid risk stratification and disposition of emergency department (ED) patients with cirrhosis. Our primary objective was to derive and internally validate a novel Cirrhosis Risk Instrument for Stratifying Post‐Emergency department mortality (CRISPE) for the outcomes of 14‐ and 30‐
Swetha Parvataneni, Michelle Haugh, Yara Sarkis, Brittany Baker, Lauren D. Nephew, Marwan S. Ghabril, Raj Vuppalanchi, Eric S. Orman, Naga P. Chalasani, Archita P. Desai, Nicholas Eric Harrison   +10 more
wiley   +1 more source