Results 131 to 140 of about 187,848 (302)

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

From a novel pathogenic SAMD9L variant to cohort‐wide insights: Whole‐genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity

British Journal of Haematology, EarlyView.
Summary Germline gain‐of‐function variants in sterile alpha motif domain–containing 9‐like (SAMD9L), located on chromosome 7q, cause a multisystem disorder characterized by bone marrow failure, immunodeficiency and variable neurological involvement. Disease evolution is frequently shaped by somatic genetic rescue (SGR), most commonly through monosomy 7,
Hadjer Dellal, Roman Klifa, Lise Larcher, Marie Passet, Tristan Celse, Laetitia Gouas, Maud Tusseau, AURAGEN Consortium, Alexis Praga, Virginie Bernard, Mathieu Fusaro   +10 more
wiley   +1 more source

Molecular screening of Heterorhabditis bacteriophora inbred lines for polymorphism and genetic crosses for the development of recombinant inbred lines

, 2019
Males and females of two entomopathogenic nematode (EPN) inbred lines, H. bact -1 and H. bact - 2, whose infective juveniles expressed contrasting performance for stress factors, were used as candidates in genetic crosses. The crosses produced an initial
Ehlers, R.U., Okolo, C.T., Chindo, P.S., Bulus, J, Molina, C   +4 more
core   +1 more source

Phenotype‐specific immune profiles and outcomes in childhood autoimmune neutropenia: A 20‐year cohort study

British Journal of Haematology, EarlyView.
Summary Childhood autoimmune neutropenia (AIN) encompasses heterogeneous entities; phenotype‐specific immunological profiles and their relationship to infection outcomes remain incompletely defined. To characterise clinical, immunological and long‐term outcomes across distinct phenotypes of childhood AIN.
Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi, Charalampos Pontikoglou, Alexandros Makis   +5 more
wiley   +1 more source

Diagnosis and management of neutropenia in adults: Expert guidance

British Journal of Haematology, EarlyView.
Severe neutropenia can result from decreased production of neutrophil precursors in the bone marrow, as in the case of severe congenital neutropenia, or from increased utilization of neutrophils or their accelerated destruction as for drug‐induced neutropenia or autoimmune neutropenia. Severe chronic neutropenia increases susceptibility to bacterial or
Karl Welte, Cornelia Zeidler, Julia Skokowa, Sabine Mellor‐Heineke, Audrey Anna Bolyard, David Dale   +5 more
wiley   +1 more source

Joint analysis of phenotypic and molecular data for genetic diversity assessment in extra-early orange maize (Zea Mays L.)

BMC Genomics
Background Maize is one of the most important cereals in the world. To maximize the potential of hybrids from heterosis, knowledge of genetic diversity is crucial.
Tégawendé Odette Bonkoungou, Idris Ishola Adejumobi, Victor Olawale Adetimirin, Baffour Badu-Apraku, Paterne Angelot Agre, Kiswendsida Romaric Nanema, Adamu Masari Abubakar, Abdalla Dao, Wende Mengesha   +8 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Quantitative Trait Loci in Inbred Lines

, 2001
Quantitative traits result from the influence of multiple genes (quantitative trait loci) and environmental factors. Detecting and mapping the individual genes underlying such 'complex' traits is a difficult task. Fortunately, populations obtained from crosses between inbred lines are relatively ideal for this - at least far more ideal than livestock ...
openaire   +2 more sources

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Translocation effects on regional and local population viability and connectivity

Conservation Biology, EarlyView.
Abstract Translocations and reintroductions aim to improve the viability of isolated populations and promote connectivity for large carnivores. However, there is no established framework for assessing their success. We used the Eurasian lynx (Lynx lynx) in western and central Europe to assess the impact of translocations on the viability of six ...
Eva Sánchez Arribas, Aimara Planillo, Joe Premier, Tobias Kürschner, Elisa Belotti, Christine Breitenmoser‐Würsten, Luděk Bufka, Rok Černe, Thomas Engleder, Urša Fležar, Tomislav Gomerčić, Miha Krofel, Tereza Mináriková, Paolo Molinari, Simona Poláková, Kateřina Poledníková, Hubert Potočnik, Magda Sindičić, Ira Topličanec, Kristina Vogt, Josefa Volfová, Sybille Wölfl, Fridolin Zimmermann, Marco Heurich, Stephanie Kramer‐Schadt, Anja Molinari‐Jobin   +25 more
wiley   +1 more source