Results 91 to 100 of about 861,250 (295)

Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity. [PDF]

Sci Rep, 2021
de Jong TV, Kim P, Guryev V, Mulligan MK, Williams RW, Redei EE, Chen H.   +6 more
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats [PDF]

, 1990
We have examined the mRNA levels and methylation patterns of the liver-specific tyrosine aminotransferase (TAT) gene in inbred female rats aged 6, 24 and 36 months.
Wiljo J.F. de Leeuw, P.Eline Slagboom, de Leeuw, Wiljo J.F., Jan Vijg, Slagboom, P.Eline, Vijg, Jan   +5 more
core   +2 more sources

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat.

PLoS ONE, 2019
Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred ...
Yazad D Irani, Emily Pulford, Lauren Mortimer, Swati Irani, Lisa Butler, Sonja Klebe, Keryn A Williams   +6 more
doaj   +1 more source

Genetic switch to lower nitrogen fertilizer dependency and enhance maize yield

iMetaOmics, EarlyView.
Transcription factor NCR1 regulates nitrate transporter NRT2.3 and controls root‐to‐shoot nitrogen transport. A superior NCR1 haplotype, lost in modern maize breeding, boosts this process. This discovery enables breeding and biotechnology to develop high‐yielding maize varieties that require less nitrogen fertilizer, reducing agricultural costs and ...
Sunil S. Gangurde, Dhliwayo Thanda, Qingguo Du, Liang Li, Jiwang Zhang, Pervez H. Zaidi, Boddupalli Maruthi Prasanna, Xuecai Zhang, Linmao Zhao, Ashish Saxena   +9 more
wiley   +1 more source

Fatores genéticos e ambientais envolvidos com o consumo de etanol e seus possíveis correlatos comportamentais nas linhagens de ratos Lewis e SHR [PDF]

, 2008
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Curso de Ciências ...
Oliveira, Ligia Fuhrmann Gonçalves de
core  

Differences in Extinction of an Appetitive Instrumental Response in Female Inbred Roman High- (RHA-I) and Low- (RLA-I) Avoidance Rats

Psicológica, 2009
An experiment was conducted with the goal of exploring strain differences between female inbred Roman High and Low Avoidance rats (RHA-I, and RLA-I, respectively) on acquisition and extinction of a food-rewarded running response in a straight alley ...
Carmen Torres, Juan M. Rosas, Albert Fernández-Teruel, Adolf Tobeña, Ángeles Agüero, María D. Escarabajal, José E. Callejas-Aguilera, Lourdes de la Torre, María J. Gómez   +8 more
doaj  

The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Infantile‐onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very‐early‐onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited.
Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram   +2 more
wiley   +1 more source

Congenital short bowel syndrome: Clinical aspects by systematic review

JPGN Reports, EarlyView.
Abstract Objectives Congenital short bowel syndrome (CSBS) is a rare intestinal disorder characterized by inborn shortening of the bowel with mainly mutations in Coxsackie and Adenovirus receptor‐like membrane protein (CLMP) and Filamin A (FLNA) genes.
Barblin Remund, Susanne Schibli, Christiane Sokollik   +2 more
wiley   +1 more source