Results 131 to 140 of about 2,317,355 (365)

Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas

open access: yesAndrology, EarlyView.
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer   +4 more
wiley   +1 more source

Electroconvulsive Thresholds of Inbred Mouse Strains

open access: yesGenomics, 2001
The electroconvulsive threshold (ECT) test is used commonly in the screening of anti-epileptic drugs in rodent models, but little is known about its genetic or mechanistic basis. Thresholds for minimal clonic, maximal tonic, or psychomotor (partial) seizures were determined in 16 different inbred mouse strains in two different laboratories.
Frankel, W N   +4 more
openaire   +3 more sources

Ascorbic acid 2‐glucoside improves survival, quality, and fertility of frozen‐thawed C57Bl/6J and C57Bl/6N mouse spermatozoa

open access: yesAndrology, EarlyView.
Abstract Background Ascorbic acid 2‐glucoside (AA2G) is a stabilized form of ascorbic acid and a potent antioxidant. Ascorbic acid is present in the testes and epididymis and helps maintain the physiological integrity of reproductive organs. Its properties have been utilized to protect spermatozoa of different species from oxidative stress.
Marcello Raspa   +2 more
wiley   +1 more source

To what extent is blood a reasonable surrogate for brain in gene expression studies: estimation from mouse hippocampus and spleen

open access: yesFrontiers in Neuroscience, 2009
Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether a second, accessible tissue could be used as a surrogate for
Matthew N Davies   +5 more
doaj   +1 more source

Therapeutic hypothermia success for hypoxic‐ischaemic encephalopathy in Latin America: Eight‐year experience in EpicLatino Neonatal Network

open access: yesActa Paediatrica, Volume 114, Issue 5, Page 922-928, May 2025.
Abstract Aim A study reported that therapeutic hypothermia (TH) did not reduce the combined prognosis of mortality and disability at 18 months, in low‐ and middle‐income countries for patients with hypoxic ischaemic encephalopathy (HIE) who received TH, suggesting its no implementation in these regions.
Carlos Fajardo   +7 more
wiley   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

open access: yesBiological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett   +4 more
wiley   +1 more source

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

open access: yesClinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl   +15 more
wiley   +1 more source

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