Results 51 to 60 of about 2,317,355 (365)

Foster dams rear fighters: strain-specific effects of within-strain fostering on aggressive behavior in male mice. [PDF]

PLoS ONE, 2013
It is well known that genes and environment interact to produce behavioral phenotypes. One environmental factor with long-term effects on gene transcription and behavior is maternal care.
Kimberly H Cox, Nina L T So, Emilie F Rissman   +2 more
doaj   +1 more source

Genetic characterization of F0 outbred and F1 inbred Swiss albino mice using microsatellite markers and their performance evaluation

Indian Journal of Animal Sciences, 2021
Swiss albino mice have been widely utilized in various biological researches worldwide. Phenotypic and fitness related traits of F0 and F1 inbred mice were estimated on 918 and 707 individual offsprings, respectively.
MITEK TARANG, PUSHPENDRA KUMAR, AMIT KUMAR, B L SAINI, SHOBHANA KAUSHAL, SHWETA SACHAN, ANUJ CHAUHAN, JAI PRAKASH, BHARAT BHUSHAN   +8 more
doaj   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

High-Resolution Maps of Mouse Reference Populations

G3: Genes, Genomes, Genetics, 2017
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J × DBA/2J, ILS/IbgTejJ × ISS ...
Petr Simecek, Jiri Forejt, Robert W. Williams, Toshihiko Shiroishi, Toyoyuki Takada, Lu Lu, Thomas E. Johnson, Beth Bennett, Christian F. Deschepper, Marie-Pier Scott-Boyer, Fernando Pardo-Manuel de Villena, Gary A. Churchill   +11 more
doaj   +1 more source

Radiation-induced myeloid leukemia in murine models. [PDF]

, 2014
The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael, Rivina, Leena, Schiestl, Robert H   +2 more
core   +2 more sources

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

Advanced Science, EarlyView.
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang, Lianhuang Li, Janet E. Sorrells, Jianxin Chen, Haohua Tu   +4 more
wiley   +1 more source

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

BMC Neuroscience, 2001
Background The presynaptic protein α-synuclein is involved in a range of neurodegenerative diseases. Here we analyze potential compensatory mechanisms in α-synuclein null mutant mice.
Schoepfer Ralf, Specht Christian G
doaj   +1 more source

Analysis of microsatellite polymorphism in inbred knockout mice. [PDF]

PLoS ONE, 2012
Previously, we found that the genotype of 42 out of 198 mouse microsatellite loci, which are distributed among all chromosomes except the Y chromosome, changed from monomorphism to polymorphism (CMP) in a genetically modified inbred mouse strain. In this
Baofen Zuo, Xiaoyan Du, Jing Zhao, Huixin Yang, Chao Wang, Yanhua Wu, Jing Lu, Ying Wang, Zhenwen Chen   +8 more
doaj   +1 more source

Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague

Advanced Science, EarlyView.
The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia, Yinon Levy, Hila Cohen, Ayelet Zauberman, David Gur, Inbal Hazan‐Halevy, Moshe Aftalion, Shani Benarroch, Erez Bar‐Haim, Orit Redy‐Keisar, Ofer Cohen, Dan Peer, Emanuelle Mamroud   +12 more
wiley   +1 more source

The effects of inbreeding on disease susceptibility:Gyrodactylus turnbulli infection of guppies, Poecilia reticulata [PDF]

, 2016
Inbreeding can threaten population persistence by reducing disease resistance through the accelerated loss of gene diversity (i.e. heterozygosity).
Altizer, Arkush, Bakke, Bijlsma, Bush, Cable, Cable, Cavalcanti, Cock van Oosterhout, Coltman, Coltman, Consuegra, Crawley, Eizaguirre, Elias, Ellison, Eszterbauer, Evans, Faria, Farr, Forsberg, Fox, Fraser, Frommen, Gilpin, Hedrick, Hedrick, Houde, IUCN/SSC, Jo Cable, Keller, Kennedy, King, MacDougall-Shackleton, Magurran, Mariette, Mathews, May, Milinski, Ortego, Penn, R Development Core Team, Ramírez, Rauch, Rijks, Roelke, Saccheri, Spielman, Thomas, van Oosterhout, van Oosterhout, van Oosterhout, van Oosterhout, van Oosterhout, Viggers, Whitehorn, Whiteman, Willow Smallbone, Zinkernagel   +58 more
core   +1 more source