Results 81 to 90 of about 2,284,318 (330)

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, EarlyView.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice

Molecular Pain, 2010
Background Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Myrczek Thekla, Häussler Annett, Albuquerque Boris, Wijnvoord Nina, Popp Laura, Tegeder Irmgard   +5 more
doaj   +1 more source

CA1 Spike Timing is Impaired in the 129S Inbred Strain During Cognitive Tasks. [PDF]

Neuroscience, 2022
Adeyelu T, Shrestha A, Adeniyi PA, Lee CC, Ogundele OM.   +4 more
europepmc   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

Aging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang, Xiaojie Liu, Hairong Lian, Yanchao Chai, Yang Zhou, Dongqi Kan, Jilong Ren, Cui Han, Jiaxin Yang   +8 more
wiley   +1 more source

Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

Frontiers in Genetics, 2019
GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function.
Megan K. Mulligan, Timothy Abreo, Sarah M. Neuner, Sarah M. Neuner, Cory Parks, Christine E. Watkins, M. Trevor Houseal, Thomas M. Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine C. Kaczorowski, Camron D. Bryant, Gregg E. Homanics, Robert W. Williams   +17 more
doaj   +1 more source

Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness-Resistant Inbred Strain. [PDF]

Behav Sci (Basel), 2021
Cabib S, Campus P, Latagliata EC, Orsini C, Tarmati V.   +4 more
europepmc   +1 more source

The establishment of the C3H inbred strain of mice for the study of spontaneous carcinoma of the mammary gland

Genetics, 1935
become interested in the use of inbred strains of mice for the study of sponta neous neoplasia. This advance has been encouraging to geneticists, who have in sisted, with great reason, that intrinsic or genetic factors do play a very important role in ...
L. Strong
semanticscholar   +1 more source

Comprehensive αβ T‐Cell Receptor Repertoire Analysis Reveals a Unique CD8+ TCR Landscape in DOCK8‐Deficient Patients

Allergy, EarlyView.
T cell receptor repertoire analysis by high‐throughput immune repertoire RNA‐sequencing in the patients with DOCK8 deficiency. Comprehensive comparisons revealed a restricted TCR repertoire diversity in the patients. Additional assessments showed potential auto‐reactive CD8+ T cell clones in the patients.Abbreviations: DOCK8, dedicator of cytokinesis ...
Ceren Bozkurt, Gökhan Cildir, Umran Aba, Rahmi Kutay Erdogan, Nicholas I Warnock I, Chung Hoow Kok, Asena Pinar Sefer, Sule Haskologlu, Sidem Didar Tekeoglu, Gülşah Merve Kılınç, Canberk Ipsir, Tugba Arikoglu, Aylin Kont Ozhan, Saliha Esenboga, Ahmet Özen, Elif Karakoç‐Aydiner, Sevgi Bilgiç Eltan, Çigdem Aydogmus, Candan Islamoglu, Kübra Baskın, Betul Karaatmaca, Ayse Metin, Deniz Çagdaş, Figen Dogu, Aydan Ikinciogullari, Safa Baris, Baran Erman   +26 more
wiley   +1 more source

Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping

Frontiers in Genetics, 2019
The interfrontal bone (IF) is a minor skeletal trait residing between the frontal bones. IF is considered a quasi-continuous trait. Genetic and environmental factors appear to play roles in its development. The mechanism(s) underlying IF bone development
Heather Zimmerman, Zhaoyu Yin, Fei Zou, Eric T. Everett, Eric T. Everett   +4 more
doaj   +1 more source

THE OCCURRENCE AND HEREDITARY BEHAVIOR OF TWO NEW DOMINANT MUTATIONS IN AN INBRED STRAIN OF DROSOPHILA MELANOGASTER [PDF]

, 1923
Margaret C. Mann
openalex   +1 more source