Results 121 to 130 of about 158,250 (266)

Unique Digital Images as Incentives in Clinical Trials: A Digital Shift Toward Meaningful Participation. [PDF]

J Med Internet Res
Tadeo X, Seres G, Wang P, Sapanel Y, Remus A, Eyal JL, Lee JK, Chesterman S, Savulescu J, Wong JE, Asplund CL, Stone RB, Tee BCK, Shokri R, Raczkowska M, Chong LM, Kwek SP, Blasiak A, Ho D.   +18 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The benefits of in situ reporting: Experimental evidence from in-the-moment surveys of public transit riders. [PDF]

Behav Res Methods
Antoun C, Frías-Martínez V, Garove A, Awasthi N, Abrar SM.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation. [PDF]

Proc Natl Acad Sci U S A
Dundon NM, Rizor EJ, Stasiak JE, Wang J, Li T, Sabugo K, Villanueva C, Barandon P, Babenko V, Beverly-Aylwin R, Stump A, Santander T, Bostan AC, Lapate RC, Grafton ST.   +14 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Impact of a provider-level incentive on smoking cessation treatment use: A secondary dataset analysis using administrative claims data and a cross-sectional survey in Japanese health check-up settings (N-EQUITY2203). [PDF]

Tob Induc Dis
Yuwaki K, Odawara M, Saito J, Fujimori M, Kuchiba A, Inoue M, Kanaoka K, Shimazu T.   +7 more
europepmc   +1 more source

Financial incentives [PDF]

British Dental Journal, 2006
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort. [PDF]

Proc Natl Acad Sci U S A
Dixon ML, Blevins E, Dweck CS, Görgen K, Knutson B.   +4 more
europepmc   +1 more source