Results 81 to 90 of about 154,380 (247)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Positive-Incentive Noise

IEEE Transactions on Neural Networks and Learning Systems
Noise is conventionally viewed as a severe problem in diverse fields, e.g., engineering, learning systems. However, this paper aims to investigate whether the conventional proposition always holds. It begins with the definition of task entropy, which extends from the information entropy and measures the complexity of the task.
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hukuki Boyutuyla Turizm İşletmesi Belgesi

Sakarya Üniversitesi Hukuk Fakültesi Dergisi/Sakarya Hukuk Dergisi
Turizm işletmesi belgesi, 2634 sayılı Turizmi Teşvik Kanunu’nda yer alan turizm belgelerinden biri, belki de en önemlisidir. 2634 Kanun’un temel hedefi, Kanun’un isminden de anlaşılacağı üzere turizm işletmelerini teşviktir.
Hüseyin Melih Çakır
doaj   +1 more source

FRESHWATER FISHERY OF THE REPUBLIC OF CROATIA [PDF]

Croatian Journal of Fisheries, 1999
As fishery, including freshwater, is very important for economy of the Republic of Croatia, the aim of this paper is to show its condition from 1995 to 1998. and also to draw a plan for fish production in 1999. The period from 1998-1999. is more stressed
Zlatko Homen, Irena Jahutka, Ante Mišura, Vesna Fuček, Josip Suić   +4 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Impact of Organizational Commitment, Incentive, and Risk Reporting through Social Media on Whistleblowing Intention

Jurnal Dinamika Akuntansi
Purposes: This study explores the impact of organizational commitment, incentives, and risks associated with reporting through social media on whistleblowing intentions.
Alim Dhisa Istiqomah, Inanda Shinta Anugrahani   +1 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Empirical Study of the Policy Processes behind Norway’s BEV-Olution

World Electric Vehicle Journal
Norway’s large battery electric vehicle (BEV) market and fleet are not the result of a comprehensive policy plan. Using the multiple streams (MS) framework and document analysis, it was identified that the most important Norwegian BEV policy decisions ...
Erik Figenbaum
doaj   +1 more source