Results 81 to 90 of about 164,362 (268)

Innumeracy and incentives: A ratio bias experiment

Judgment and Decision Making, 2007
The Ratio-Bias phenomenon, observed by psychologist Seymour Epstein and colleagues, is a systematic manifestation of irrationality. When offered a choice between two lotteries, individuals consistently choose the lottery with the greater number of ...
Donald Dale, Jeffrey Rudski, Adam Schwarz, Eric Smith   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Factors influencing performance motivation of Accredited Social Health Activists, the community health volunteers of India - A mixed method study

Journal of Family Medicine and Primary Care
Aims and Objectives: This study aims to explore the factors influencing the performance motivation of Accredited Social Health Activists (ASHAs) across four Indian states with different incentive models.
Richa Sharma, Srishti Gulati, Gautami Panigrahi, Ananth Kumar, Gurinder B Singh, Atul Kotwal   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hukuki Boyutuyla Turizm İşletmesi Belgesi

Sakarya Üniversitesi Hukuk Fakültesi Dergisi/Sakarya Hukuk Dergisi
Turizm işletmesi belgesi, 2634 sayılı Turizmi Teşvik Kanunu’nda yer alan turizm belgelerinden biri, belki de en önemlisidir. 2634 Kanun’un temel hedefi, Kanun’un isminden de anlaşılacağı üzere turizm işletmelerini teşviktir.
Hüseyin Melih Çakır
doaj   +1 more source

FRESHWATER FISHERY OF THE REPUBLIC OF CROATIA [PDF]

Croatian Journal of Fisheries, 1999
As fishery, including freshwater, is very important for economy of the Republic of Croatia, the aim of this paper is to show its condition from 1995 to 1998. and also to draw a plan for fish production in 1999. The period from 1998-1999. is more stressed
Zlatko Homen, Irena Jahutka, Ante Mišura, Vesna Fuček, Josip Suić   +4 more
doaj