Results 171 to 180 of about 118,970 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Pay for Performance Incentive Sysrems and Organizatinal : Performances in a Illumination Lamp Company : a Survey Study

, 2006
This paper explores the relationships between the design and use of pay-forperformance incentive systems and some outcome measures. Analyzing 158 questionnaire survey data in a illuminationlamp company, we find evidence that the design and use of pay-for-
相原, 基大, 窪田, 祐一, 福田, 直樹, 近藤, 隆史   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Incentive Effects of Retirement Income Transfers

The paper explores the incentive effects of retirement income transfers – essentially, non-contributory cash transfers aimed at reducing poverty among the elderly.
Jimenez-Martin, Sergi, Piggot, John, Robalino, David   +2 more
core  

Motivating knowledge agents : can incentive pay overcome social distance? [PDF]

This paper studies the interaction of incentive pay and social distance in the dissemination of information. We analyse theoretically as well as empirically the e ect of incentive pay when agents have pro-social objectives, but also preferences over ...
Berg, Erland, Ghatak, Maitreesh, Roy, Sanchari, Manjula, R., Rajasekhar, D.   +4 more
core  

Design of reputation-driven blockchain sharding consensus and incentive mechanism

网络与信息安全学报
The PBFT (Practical Byzantine Fault Tolerance) consensus algorithm was confronted with several challenges in the blockchain sharding environment, including high communication complexity, random leader election, node insecurity, and insufficient ...
TIAN Hanwen, ZHANG Shuhui, WANG Lianhai, XU Shujiang, SHAO Wei   +4 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Should we combine incentive payments and tendering for efficiently purchasing conservation services from landholders?

Policy makers aiming to get private landholders to provide non-marketed environmental services need to provide efficient economic incentives. Two ideas have been explored to achieve this: linking contract payments to environmental outcomes and putting ...
Schilizzi, Steven, Latacz-Lohmann, Uwe, Breustedt, Gunnar   +2 more
core  

Unique Digital Images as Incentives in Clinical Trials: A Digital Shift Toward Meaningful Participation. [PDF]

J Med Internet Res
Tadeo X, Seres G, Wang P, Sapanel Y, Remus A, Eyal JL, Lee JK, Chesterman S, Savulescu J, Wong JE, Asplund CL, Stone RB, Tee BCK, Shokri R, Raczkowska M, Chong LM, Kwek SP, Blasiak A, Ho D.   +18 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source