Results 151 to 160 of about 1,986 (212)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

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Analysis of incentive mechanism in Repchain

2021 26th International Computer Conference, Computer Society of Iran (CSICC), 2021
In recent years, the blockchain that is the basis of Bitcoin has received much attention. However, the blockchain also faces many challenges, such as security and scalability, which have been the subject of recent researches. Much work has been done to solve the scalability problem in blockchain; one of these methods is sharding.
Mojdeh Hemati, Mehdi Shajari
openaire   +1 more source

Robustness evaluation of incentive mechanisms

International Joint Conference on Autonomous Agents and Multiagent Systems, 2013
A general assumption for incentive mechanisms is that all agents are rational and seek to maximize their utility. When some agents are irrational and launch various attacks, these mechanisms may fail to work. To address the issue of evaluating the robustness of incentive mechanisms, we propose a robustness metric in this paper.
Yuan Liu 0002, Jie Zhang 0002
openaire   +2 more sources

Incentive-Compatible Escrow Mechanisms

Proceedings of the AAAI Conference on Artificial Intelligence, 2011
The most prominent way to establish trust between buyers and sellers on online auction sites are reputation mechanisms. Two drawbacks of this approach are the reliance on the seller being long-lived and the susceptibility to whitewashing.
Witkowski, Jens, Seuken, Sven, Parkes, David   +2 more
openaire   +2 more sources

Truthful incentive mechanisms for crowdsourcing

2015 IEEE Conference on Computer Communications (INFOCOM), 2015
With the prosperity of smart devices, crowdsourcing has emerged as a new computing/networking paradigm. Through the crowdsourcing platform, service requesters can buy service from service providers. An important component of crowdsourcing is its incentive mechanism. We study three models of crowdsourcing, which involve cooperation and competition among
Xiang Zhang 0005, Guoliang Xue, Ruozhou Yu, Dejun Yang, Jian Tang 0008   +4 more
openaire   +1 more source

Blockchain-Based Incentive Mechanisms: Single Incentive Mechanism and Compound Incentive Mechanism

Applied and Computational Engineering
With the wide application of blockchain in data sharing scenarios such as smart healthcare, the Internet of Things, and federated learning, how to maintain trusted collaboration and motivate nodes to continuously participate under the premise of privacy protection has become a key issue.
Yibo Han, Yitao Han
openaire   +1 more source