Results 91 to 100 of about 1,955,609 (374)
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Merger Efficiency and Managerial Incentives [PDF]
, 2013 We consider a two-stage principal-agent model with limited liability in which a CEO is employed as agent to gather information about suitable merger targets and to manage the merged corporation in case of an acquisition.
Kräkel, Matthias, Müller, Daniel
core +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Monetary Incentives in Mail Surveys [PDF]
, 1975 Eighteen empirical studies from fourteen different researchers provide evidence that prepaid monetary incentives have a strong positive impact on the response rate in mail surveys.
Armstrong, J. Scott
core +2 more sources
Incentivizing P/CVE Research, Evaluation, & Program Participants
Journal for Deradicalization, 2022 Incentivizing research or evaluation participants can be crucial toward reducing data collection timeframes and obtaining sufficient sample sizes (i.e., to reduce the risks of obtaining null or misleading findings).
Michael J. Williams
doaj
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
ASPECTS OF THE PROBLEM OF INCENTIVES FOR IMPLEMENTATION OF HEAT PUMPS
Problems of the Regional Energetics, 2011 There were identified reasons for incentives of the implementation of heat pumps by the Governement of industial developped countries. It is considered scheme of obtaining of benefits for the Governement as a result of heat pump incentives.
Berzan V., Robu S., Sit M.
doaj
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Ecology and SocietyLand users’ motives for participating in conservation and restoration activities are influenced by the local and broader scale contexts and are often determined by their perceptions of the current situation.
Thozamile S Yapi +2 more
doaj +1 more source