Results 121 to 130 of about 1,955,609 (374)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

open access: yesFEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio   +9 more
wiley   +1 more source

PRACTICES OF EDUCATION MANAGERS TO INCREASE TEACHERS’ ENTHUSIASM FOR ACHIEVEMENT OF DESIRED RESULTS IN WORK

open access: yesNovìtnâ Osvìta, 2018
The current study explored the practices of educational managers to increase teachers’ enthusiasm for the achievement of desired results in work because educational managers and teachers are the important part of educational institutions and without ...
Abdul Shakoor, Muhammad Javed Iqbal
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Incentives in Organizations [PDF]

open access: yesJournal of Economic Perspectives, 1998
In this paper, the author summarizes four new strands in agency theory that help him think about incentives in real organizations. As a point of departure, The author begins with a quick sketch of the classic agency model. He then discusses static models of objective performance measurement that sharpen Kerr's argument; repeated-game models of ...
openaire   +4 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Are local economic development incentives promoting job growth? An empirical case study [PDF]

open access: yes, 2008
At a time when cities are competing with one another to attract or retain jobs within a globalizing economy, city governments are providing an array of financial incentives to stimulate job growth and retain existing jobs, particularly in high cost ...
Fuerst, Franz, Mollenkopf, John
core  

Fiscal Incentives Revisited [PDF]

open access: yes
This short paper attempts to clarify some of the issues and provide suggestions for reforms in the fiscal incentive system. In particular, it focuses on the Investment Incentive System embodied in the Omnibus Investment Code.
Medalla, Erlinda M.
core   +5 more sources

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