Results 301 to 310 of about 2,027,828 (376)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluating a Mobile Health Intervention (GUIDE App) for First Responders, Military Personnel, and Veterans: Randomized Controlled Trial.

J Med Internet Res
Dunphy MK, Nuske HJ.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Assessing the Willingness to Work in Rural Areas and Associated Factors Among Medical Students at King Saud University in Riyadh, Saudi Arabia. [PDF]

Cureus
Alobaid N, BinMoammar T, Alotaibi AA, Fakeeha BA, Almatri AM, Alwahibi M, Almufarrej A, Aldubaib NA, Alnazzawi E.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Cultural Incentive Learning: How Culture Shapes Acquisition of Values. [PDF]

Evol Anthropol
Rigoli F, Lennon J.
europepmc   +1 more source

Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis. [PDF]

Schizophr Bull
Shackman AJ, Smith JF, Orth RD, Savage CLG, Didier PR, McCarthy JM, Bennett ME, Blanchard JJ.   +7 more
europepmc   +1 more source

Impact of behavioral economics to improve antihypertensive therapy adherence, a pilot randomized controlled trial in Los Angeles. [PDF]

Sci Rep
Linnemayr S, Ghai I, Palimaru A, Barajas D, Vallejo R, Blyler CA, Morales EM, De Guzman M, Joung SY, Ungar S, Ebinger JE.   +10 more
europepmc   +1 more source