Results 121 to 130 of about 2,598,216 (342)

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Rethinking Security Incident Response: The Integration of Agile Principles [PDF]

open access: yesarXiv, 2014
In today's globally networked environment, information security incidents can inflict staggering financial losses on organizations. Industry reports indicate that fundamental problems exist with the application of current linear plan-driven security incident response approaches being applied in many organizations.
arxiv  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Cycles that are incidence equivalent to zero [PDF]

open access: yesarXiv, 2015
In this paper, we apply incidence divisors constructed through Archimedean height paring to prove that Griffiths' conjecture on incidence equivalence is correct for a smooth projective variety with first non-vanishing cohomology. (Incidence divisor is insignificant. Theorem 5.1 is significant, but the proof of it presented here is incorrect.)
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

open access: yesFEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran   +3 more
wiley   +1 more source

Methods used by WHO to estimate the Global burden of TB disease [PDF]

open access: yesarXiv, 2016
This paper describes methodological details used by WHO in 2015 to estimate TB incidence, prevalence and mortality. Incidence and mortality are disaggregated by HIV status, age and sex. Methods to derive MDR-TB burden indicators are detailed. Four main methods were used to derive incidence: (i) case notification data combined with expert opinion about ...
arxiv  

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