Results 31 to 40 of about 2,598,216 (342)
Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance
Immunotherapy has developed rapidly and has gradually become one of the important methods for treatment of gastric cancer (GC). The research on tumor infiltrating immune cells (TIICs) and immune-related genes in the tumor microenvironment (TME) greatly ...
An Zhi Zhang+16 more
doaj +1 more source
Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen+3 more
wiley +1 more source
Experimental study on the optimization of ANM33 release in foam cells
Given the miR-33’s mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 ...
Yuan Chen+6 more
doaj +1 more source
piR-1919609 Is an Ideal Potential Target for Reversing Platinum Resistance in Ovarian Cancer
Purpose PIWI-interacting RNAs (piRNAs) are a type of noncoding small RNA that can interact with PIWI-like RNA-mediated gene silencing (PIWIL) proteins to affect biological processes such as transposon silencing through epigenetic effects.
Ying Yan MD+9 more
doaj +1 more source
The ever increasing participation in aquatic recreational activities is a major factor in the increasing number of deaths due to accidental immersion. Some of these deaths occur while undergoing resuscitative efforts immediately following rescue, on admission to hospital, or even up to 19 days after the immersion incident. Drowning, either acute or its
J. F. Rivers, F. St C. Golden
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Factors modulating 99mTc‐MAA planar lung dosimetry for 90Y radioembolization
Abstract Purpose To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99mTc‐macro‐aggregated albumin (99mTc‐MAA) planar imaging for treatment planning of 90Y‐microsphere radioembolization.
Benjamin P. Lopez+4 more
wiley +1 more source
RNA-binding proteins (RBPs) are a class of proteins that primarily function by interacting with different types of RNAs and play a critical role in regulating the transcription and translation of cancer-related genes.
Chenghao Liu+9 more
doaj +1 more source
Aberrant activation of CYR61 enhancers in colorectal cancer development
Background High expression of secreted matricellular protein cysteine-rich 61 (CYR61) correlates with poor prognosis in colorectal cancer (CRC). Aberrant enhancer activation has been shown to correlate with expression of key genes involved in cancer ...
Lingzhu Xie+12 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr+4 more
wiley +1 more source