Results 41 to 50 of about 109,309 (258)
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Incidental findings, genetic screening and the challenge of personalisation
Annali dell'Istituto Superiore di Sanità, 2014 Genetic tests frequently produce more information than is initially expected. Several documents have addressed this issue and offer suggestions regarding how this information should be managed and, in particular, concerning the expedience of revealing ...
Carlo Petrini, Enrico Alleva
doaj +1 more source
Why genomics researchers are sometimes morally required to hunt for secondary findings
BMC Medical Ethics, 2020 Background Genomic research can reveal ‘unsolicited’ or ‘incidental’ findings that are of potential health or reproductive significance to participants.
Julian J. Koplin +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT The International Paediatric Oncology Society Global Mapping Programme aims to collect data on global paediatric oncology services by continent, with Africa and Latin America completed. This study reports on the methodology and lessons learned for Oceania, a unique continent with resource disparity across countries, multiple small island ...
Trisha Soosay Raj +16 more
wiley +1 more source
Significance of ultrasonography in detection of incidental renal cell carcinoma
Urology Research and Practice, 2019 Objective: Incidental detection of renal cell carcinoma (RCC) has increased significantly in recent years because of widespread use of abdominal imaging, especially abdominal ultrasonography.
Zeki Bayraktar +2 more
doaj +2 more sources
Incidentalome from Genomic Sequencing: A Barrier to Personalized Medicine?
EBioMedicine, 2016 Background: In Western cohorts, the prevalence of incidental findings (IFs) or incidentalome, referring to variants in genes that are unrelated to the patient's primary condition, is between 0.86% and 8.8%.
Saumya Shekhar Jamuar +17 more
doaj +1 more source
Incidental Findings in Pediatric Research [PDF]
Journal of Law, Medicine & Ethics, 2008 Incidental research findings, as defined in this symposium’s consensus paper, are unexpected findings discovered in the course of research but “beyond the aims of the study.” These include findings generated by research methodology, such as imaging or genetic analysis, findings related to clinical screening for inclusion or exclusion, or direct ...
Benjamin S, Wilfond +1 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Cardiac angiosarcoma: an unexpected diagnosis
Autopsy and Case Reports, 2014 Cardiac angiosarcoma is a rare entity. The incidence through autopsy findings ranges between 0.001% and 0.03%. The disease usually presents with non-specific symptoms, although asymptomatic cases are frequent; therefore, diagnosis is unexpected and ...
Milton Roberto Furst Crenitte +3 more
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