Results 251 to 260 of about 291,670 (308)

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer. [PDF]

Front Public Health
Jaylet T, Chauhan V, Mezquita L, Boroumand N, Laurent O, Elihn K, Lundholm L, Armant O, Audouze K.   +8 more
europepmc   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Early-onset lung cancer in Asia: a narrative review. [PDF]

Front Oncol
De Guzman RB.
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Predict Nicotine Pharmacokinetics of Nicotine Pouches Under Naturalistic Use Conditions

The Journal of Clinical Pharmacology, EarlyView.
Abstract Adult users of traditional tobacco products like combustible cigarettes (CC) or moist smokeless tobacco (MST) products can reduce exposure to toxicants by switching to potentially less harmful alternatives such as tobacco‐free nicotine pouches (NP). Nicotine exposure assessment is an important consideration to determine the switching potential
Ali Salehi, Mohamadi A. Sarkar, Jennifer H. Smith, Ali A. Rostami   +3 more
wiley   +1 more source

Dual Targeting of Inflammatory and Immune Checkpoint Pathways to Overcome Radiotherapy Resistance in Esophageal Squamous Cell Carcinoma. [PDF]

J Inflamm Res
Qu Z, Shi L, Wang P, Zhao A, Zheng X, Yin Q.   +5 more
europepmc   +1 more source

A Randomized Crossover Clinical Study to Assess the Effect of Oral Nicotine Pouches Used for Different Durations on Plasma Nicotine Pharmacokinetics in Healthy Oral Pouch Consumers

The Journal of Clinical Pharmacology, EarlyView.
Abstract Oral nicotine pouches (NPs), although addictive and not risk‐free, have potential application for a tobacco harm reduction approach. This study aims to further characterize their ability to deliver nicotine effectively. This randomized seven‐way crossover PK study in healthy oral pouch consumers evaluated 11 and 20 mg NPs used for 10, 20, and ...
David Azzopardi, Elaine Brown, Filimon Meichanetzidis, Stacy Fiebelkorn, Linsey E. Haswell, George Hardie, Michael McEwan   +6 more
wiley   +1 more source

A framework for evaluating less-than-lifetime exposures: advancing toxicological risk assessment for drinking water quality. [PDF]

Arch Toxicol
Majid S, Reus A, Hoondert R, Blokker M, Dash A, Houtman C, Schriks M, Dingemans MML.   +7 more
europepmc   +1 more source

Preoperative Multifrequency MR Elastography for Stratifying Wnt/β‐Catenin Pathway and Microvascular Invasion Phenotypes in Hepatocellular Carcinoma

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The Wnt/β‐catenin signaling pathway and microvascular invasion (MVI) are associated with the prognosis of hepatocellular carcinoma (HCC). Purpose To evaluate the Wnt/β‐catenin pathway and MVI states using preoperative MR elastography (MRE). Study Type Prospective.
Huanhuan Chong, Yuchen Yang, Ruokun Li, Weiwei Rui, Jiahao Zhou, Yikun Wang, Qi Lin, Jing Guo, Huimin Lin, Fuhua Yan   +9 more
wiley   +1 more source

From COPD to Smoke-Related Arteriopathy: The Mechanical and Immune-Inflammatory Landscape Underlying Lung Cancer Distant Spreading-A Narrative Review. [PDF]

Cells
Stella GM, Bertuccio FR, Novy C, Bortolotto C, Salzillo I, Perrotta F, D'Agnano V, Conio V, Arici V, Cerveri P, Bianco A, Corsico AG, Bozzani A.   +12 more
europepmc   +1 more source