Results 91 to 100 of about 4,931,008 (278)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Salvando la brecha digital. La plasticidad del cerebro joven frente a los círculos neuronales ya consolidados de un cerebro adulto [PDF]

open access: yes, 2010
El ritmo de las TICS nos sitúa con una gran diferencia no sólo digital, sino también cerebral, la cual provoca un enorme antagonismo entre los denominados nativos e inmigrantes digitales.
Marcos Sánchez, Vanesa
core  

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

The impact of digital literacy and technology adoption on financial inclusion in Africa, Asia, and Latin America

open access: yesHeliyon
Emerging countries face specific challenges in mobilizing the transformative potential of digital technology to achieve financial inclusion. While previous studies emphasize the role of digital infrastructure and technology adoption in financial ...
N. Adel
semanticscholar   +1 more source

Impact of digital finance on financial inclusion and stability

open access: yesBorsa Istanbul Review, 2018
This article provides a discussion on some issues associated with digital finance – an area which has not been critically addressed in the literature.
Peterson K. Ozili
semanticscholar   +1 more source

La alfabetización digital para personas con discapacidad : un enfoque mediático [PDF]

open access: yes, 2016
Desde el surgimiento de las nuevas tecnologías e Internet, las personas con diversidad funcional se han enfrentado a una brecha digital que, en mayor o menor medida, llega hasta la actualidad.
García-Prieto, Victoria
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Los Núcleos de Acceso al Conocimiento

open access: yesTextos y Contextos desde el Sur, 2019
A más de quince años de la puesta en marcha de Planes, Programas y Agendas para la Sociedad de la Información en la región Latinoamericana, nos proponemos revisar las políticas públicas para la inclusión digital desarrolladas en Argentina ...
Silvia Lago Martínez   +2 more
doaj  

Formación docente em línea: la inclusion sociodigital más allá del acceso a las tecnologias digitales de informacíon y comunicación [PDF]

open access: yes, 2017
Este artigo apresenta dados parciais da pesquisa de doutoramento Formação de professores, Literacia Digital e Inclusão Sociodigital: Estudo de caso em curso a distância da Universidade Federal do Tocantins.
Alves, Elaine Jesus   +1 more
core  

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