Results 71 to 80 of about 674,563 (236)

Salvando la brecha digital. La plasticidad del cerebro joven frente a los círculos neuronales ya consolidados de un cerebro adulto [PDF]

, 2010
El ritmo de las TICS nos sitúa con una gran diferencia no sólo digital, sino también cerebral, la cual provoca un enorme antagonismo entre los denominados nativos e inmigrantes digitales.
Marcos Sánchez, Vanesa
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Inclusión Digital y Telecentros: Análisis de experiencias de tres telecentros en Alto Paraná - Paraguay

Academo, 2014
Para el logro de una sociedad basada en la inclusión sus beneficios deben ser compartidos por todos, esto se aplica también a las Tecnologías de la Información y Comunicación.
María Felicia Chamorro
doaj  

A quick and effective estimation of algal density by turbidimetry developed with Chlorella vulgaris cultures [PDF]

, 2015
El uso de Chlorella vulgaris Beijerinck como alimento para el zooplancton implica la necesidad de optimizar el cultivo de algas para mantener su crecimiento en el tiempo.
Altamirano, Pablo Rodrigo, Benitez, Hernan Hugo, Claps, Maria Cristina, Ferrando, Noelia Soledad, Gabellone, Nestor Adrian   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Formación docente em línea: la inclusion sociodigital más allá del acceso a las tecnologias digitales de informacíon y comunicación [PDF]

, 2017
Este artigo apresenta dados parciais da pesquisa de doutoramento Formação de professores, Literacia Digital e Inclusão Sociodigital: Estudo de caso em curso a distância da Universidade Federal do Tocantins.
Alves, Elaine Jesus, Silva, Bento Duarte da   +1 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Diseño de experiencia de usuario : un requisito científico para la Inclusión socio - digital [PDF]

, 2016
La investigación social en el campo de la interacción hombre computadora o Human computer interaction, provee una nueva disciplina que permite comprender el fenómeno contemporáneo de la mediatización de la vida a través de las tecnologías de información.
García Aramburu, Agustín, Godoy, Marcelo, Paz, Lorena, Stanziola, Enrique   +3 more
core  

Usability and Feasibility Study of a Remote Cognitive Behavioral Therapy System with Long-Term Unemployed Women [PDF]

, 2017
We present the results of the use of a cognitive behavioral therapeutic intervention tool to improve the mental, physical, and social health of a group of long-term unemployed women in Spain.
Aguilera, A, Ferrás, C, García, Y, Ávila, P   +3 more
core   +1 more source