Results 131 to 140 of about 1,645,589 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reforma de salud en Ecuador: nunca más el derecho a la salud como un privilegio

Revista Peruana de Medicina Experimental y Salud Pública
El proceso de reforma de la salud que experimenta el Ecuador ha tenido logros importantes, porque se da en el marco de una nueva Constitución de la República, que permitió la incorporación de demandas sociales históricas surgidas de las críticas al ...
Miguel Malo-Serrano, Nicolás Malo-Corral   +1 more
doaj   +2 more sources

El rollo de Anakleta, cortometraje animado el arte como medio para la resignificación de las mujeres adolescentes en condición de vulnerabilidad y riesgo [PDF]

, 2015
EL ROLLO DE ANAKLETA, CORTOMETRAJE ANIMADO es un proyecto que fija su atención en el arte como espacio de expresión para activar esferas de inclusión y caminos para la transformación social.
Forero, Gustavo Adolfo, León Caballero, Oswaldo, Medina Sánchez, Andrea Johanna, Rodríguez Ortiz, Lina Alexandra, Serrano Esguerra, Patricia   +4 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Continuidad y ruptura en el contexto de una institución para la inclusión social [PDF]

, 2015
Treballs Finals de Grau Antropologia Social i Cultural, Facultat de Geografia i Història, Universitat de Barcelona, Curs: 2014-2015, Tutor: Ignasi TerradasLas instituciones sociales privadas, así como las públicas, imponen un conjunto de maneras de hacer
Taibi Cicaré, Facundo
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

El valor del tiempo en los procesos educativos de integración e inclusión social [PDF]

, 2011
L’estudi dels temps educatius i socials des d’una perspectiva d’inclusió social i d’atenció a la diversitat suposa nous reptes per a la Pedagogia- Educació Social, tant pels múltiples elements que conformen les pràctiques educatives com per la ...
Alonso Pardo, Paula, Teijeiro Bóo, Yésica, Varela Crespo, Laura   +2 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source