Results 161 to 170 of about 792,574 (264)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Sectoral Differences in Psychosocial Well-Being: The Role of Work Environment Factors Across Public Administration, Healthcare, Pharmaceutical, and Energy Services. [PDF]

Behav Sci (Basel)
Nagle E, Skrūzkalne I, Seņkāne S, Andersen O, Nyberg A, Zamalijeva O, Rajevska O, Griškēviča I, Ivanovs A, Reine I.   +9 more
europepmc   +1 more source

El papel de la educación y los museos en la inclusión social. Una contribución desde la animación sociocultural.

, 2012
Andrés Escarbajal de Haro, Silvia Margarita Martínez de Miguel López   +1 more
openalex   +1 more source

El uso de las redes sociales en la autoformación docente para actuar en la inclusión de alumnos con trastorno del espectro autista

, 2022
Agnes Harumi Iamaguchi
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Normality, Belonging and Welfare Inclusion among Young People with Drug Problems: A Commentary. [PDF]

Nordisk Alkohol Nark
Sylvin MG.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Physical Activity as a Tool for Social Inclusion in Multiple Sclerosis: A Systematic Review of Qualitative, Quantitative, and Mixed-Methods Evidence. [PDF]

Sports (Basel)
Marzoli F, Cardinali L, Di Pinto G, Campanella M, Colombo A, Ferrari D, Marcelli L, Silvestri F, De Giorgio A, Velardi A, Curzi D, Guidetti L.   +11 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The role of artificial intelligence in promoting kindness in society: A qualitative study to advance well-being, equity, and positive social change. [PDF]

Health Psychol Open
Ebrahimian A, Mansourian M, Vahidi S, Alavi F.   +3 more
europepmc   +1 more source