Results 121 to 130 of about 193,277 (317)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Nonlocal Nonlinear Fractional-Order Sequential Hilfer–Caputo Multivalued Boundary-Value Problems
MathematicsThis paper is concerned with the investigation of a nonlocal sequential multistrip boundary-value problem for fractional differential inclusions, involving (k1,ψ1)-Hilfer and (k2,ψ2)-Caputo fractional derivative operators, and (k2,ψ2)- Riemann–Liouville ...
Sotiris K. Ntouyas +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Library of Omissions and Inclusions
, 2016 The Library of Omissions and Inclusions is a growing long-term and community-built platform. Catalogued online and accessible in form of temporary reading rooms (traveling to various contexts and communities) this collection of materials builds a body of
Weinmayr, Eva,
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Detection of hopanes and steranes in single oil-bearing fluid inclusions using ToF-SIMS
, 2009 Hopanes and steranes are key biomarkers when tracking early evolution of life on Earth. A potential contamination-free source of Precambrian biomarkers is oil-bearing fluid inclusions as the oil has been secluded from the environment since the formation ...
Siljeström, Sandra, +5 more
core
Second Order Dynamic Inclusions
, 2005 The theory of dynamic inclusions on a time scale is introduced, hence accommodating the special cases of differential inclusions and difference inclusions.
Bohner, Martin, Tisdell, Christopher C.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Evolution of Cellular Inclusions in Bietti’s Crystalline Dystrophy
, 2010 Bietti’s crystalline dystrophy (BCD) consists of small, yellow-white, glistening intraretinal crystals in the posterior pole, tapetoretinal degeneration with atrophy of the retinal pigment epithelium (RPE) and “sclerosis” of the choroid; in addition ...
Emiko Furusato +2 more
core
CrystalsThe Malysheva emerald mine (Urals, Russia) boasts a long history and extraordinary emerald output. However, recent studies indicate that Malysheva emeralds share highly similar inclusion varieties, UV-visible-near infrared (UV-Vis-NIR) spectra, and ...
Yu-Yu Zheng +3 more
doaj +1 more source