Results 91 to 100 of about 1,231,942 (313)
Technology Changes Everything: Inclusive Tech and Jobs for a Diverse Workforce: Pierce Memorial Foundation Report [PDF]
, 2019 This document serves as the final report to the Pierce Foundation for funding to support the design and implementation of a 1.5-day Forum entitled “Technology Changes Everything: A Forum on Inclusive Tech and Jobs for a Diverse Workforce” conducted in ...
Bruyere, Susanne M, Dr.
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
HeritageThe research problems addressed in this article pertain to the limited understanding and insufficient availability of digital storytelling guidelines for elderly and physically impaired individuals in museum presentations. The objective of this review is
Kittichai Kasemsarn +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
LandThis article outlines the development of an inter-scale analytical tool designed to evaluate urban, intermediate, and domestic spaces from a gender perspective.
Irene Ros Martín +2 more
doaj +1 more source
Innovating With People - The Business of Inclusive Design [PDF]
, 2010 This book brings together the complex academic knowledge that exists in inclusive design and presents it in an accessible format suitable for trade and industry.
Eikhaug, Onny, Gheerawo, Rama
core
Disruptive design innovation: reflections on the relationship of design, science and art [PDF]
, 2010 The title of designer conveys a large number of historical, cultural, philosophical drivers and working practises that effectively range from the traditional engineer through to the individual interested in personal expression.
Arthur, L, Breedon, P
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Designing a visible city for visually impaired users [PDF]
, 2009 This paper reports on an ongoing doctoral research project which aims to identify the main barriers to access within the built environment for persons with a visual impairment.
Grant, P.M., White, Robert W.
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source