Results 111 to 120 of about 1,231,942 (313)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Perceived Inclusivity in Mobility Aids Use: A Qualitative Study in Iran

open access: yesDisabilities
Despite inclusive design focusing on improving environmental accessibility for mobility aid (MA) users, it often fails to ensure true inclusivity due to mismatches between interventions and user perceptions. Therefore, understanding MA users’ perceptions
Mohsen Rasoulivalajoozi   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Function-oriented Inclusive Design [PDF]

open access: yesAnnals of computer science and information systems, 2014
Markus Modzelewski, Michael Lawo
doaj   +1 more source

Modelling complexity of gender as an agent of change [PDF]

open access: yes, 2006
Social inclusion continues to develop as a key issue in responsible design practices. To date, we have witnessed change in the development of inclusivity for the aged, and the physically and mentally challenged, but little more than exploration by ...
Hilton, Kevin
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Desain Pembelajaran Untuk Guru Tk Inklusif [PDF]

open access: yes, 2011
Developing an Instructional Design to Improve Kindergarten Teachers' Competencies in the Perspective of Inclusive Education. This study aims to develop an instructional design set to improve kindergarten teachers' competencies in inclusive education in ...
Suparno, S. (Suparno)
core  

Home - About - Disclaimer - Privacy