Results 121 to 130 of about 1,226,951 (342)

Inclusive Design in the Field of Education from the Paradigm of Early Intervention. [PDF]

open access: yesChildren (Basel), 2021
Benítez-Lugo ML   +5 more
europepmc   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

The Summit on Creativity and Aging in America [PDF]

open access: yes, 2016
This report looks at how the federal government can leverage the arts to foster healthy aging and inclusive design for this growing population. This white paper features recommendations from the May 2015 Summit on Creativity and Aging in America, a ...
Ace Everett   +7 more
core  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Built Heritage Meets Inclusive Design

open access: yesOchrona Dziedzictwa Kulturowego
Inclusive design aims to accommodate as many people as possible by considering the diversity of human abilities and conditions during design. This raises challenges in relation to built heritage: proposals to make a building more inclusive may encounter
Lene Van de Bemdt   +2 more
doaj   +1 more source

INVESTIGATING INCLUSIVE DESIGN OF SHARED AUTOMATED VEHICLES WITH FULL-SCALE MODELING. [PDF]

open access: yesProc Hum Factors Ergon Soc Annu Meet, 2021
Tabattanon K, Schuler PT, D'Souza C.
europepmc   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

The Design Process in the Development of an Online Platform for Personalizing Wearable Prostheses: A Preliminary Approach

open access: yesDesigns
This study is part of the research project Dep-Project: Design and Embodiment of Wearable Prostheses, funded by the Foundation for Science and Technology (FCT), whose main objective is the development of wearable myoelectric prostheses for upper limbs ...
Sara Peixoto   +4 more
doaj   +1 more source

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