Results 131 to 140 of about 1,231,942 (313)

The Accessible Toilet Resource [PDF]

, 2007
Extract: This Accessible Toilet Design Resource has been produced from new primary research carried out within VivaCity 2020, a large university-based research consortium that is developing tools and resources to support the design of socially inclusive ...
Bichard, J, Greed, C, Hanson, J
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Communication with Disabled Fans at Sports Events: Approaches, Challenges, and Opportunities

Societies
This study investigates how effectively European football clubs communicate and implement accessibility features for disabled fans, aiming to develop a comprehensive framework for evaluating these practices. Using a multi-phase research design, the study
Martin Koželj, Iztok Podbregar, Maja Meško, Irena Nančovska Šerbec   +3 more
doaj   +1 more source

Somatopia - Creative computing through inclusive design [PDF]

, 2016
The overarching aim of our research has been bridge the gap between emotionally compelling, open source technology innovation and disenfranchised groups who could benefit from the opportunity to engage with such technologies “as themselves”1.
Keay-Bright, Wendy, Lewis, Joel Gethin
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Multisensory inclusive design with sensory substitution. [PDF]

Cogn Res Princ Implic, 2020
Lloyd-Esenkaya T, Lloyd-Esenkaya V, O'Neill E, Proulx MJ.   +3 more
europepmc   +1 more source

Inclusive Job Design [PDF]

Abstract In the modern labor market, we often unconsciously adhere to ‘ableist’ notions of what constitutes an ‘ideal worker,’ a ‘normal job,’ and ‘ordinary work.’ These ingrained norms create a divide between what is considered normal and abnormal, able and disabled, ideal and deficient.
openaire   +1 more source