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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Designing diversity: ethical virtual agents for effective dermatological training
This paper discusses the importance of diversity and inclusivity in designing virtual agent simulations for dermatology. As virtual reality (VR) technology become increasingly utilized in dermatological diagnosis, treatment, and training, there is a need
Melisa Kujević +4 more
doaj +1 more source
Inclusive Design in Assisted Instruction [PDF]
Much instruction starts with abstract representations for which learners have insufficient foundation [1]. The British Standard, BS 7000-6:2005 Guide to Managing Inclusive Design, provides a comprehensive framework that can help all private enterprises ...
Gabriel ZAMFIR
core
Inclusive design: developing students' knowledge and attitude through empathic modelling [PDF]
Cataloged from PDF version of article.To enhance the function and quality of built environments, designers should consider all possible users in their design projects.
Altay, B., Demirkan, H.
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Universal Design in Interior Architecture Education: The Case of Store Design
Universal design is a user-focused designing approach that involves cultural, physical, mental and dimensional aspects and takes into account the needs of different personal characteristics.
Sariye Selhan Yalçın Usal +1 more
doaj
Design factors for a successful Shared Space Street (SSS) design
The concept of Shared Space Street (SSS) has the potential to bring many benefits to a city. Those include promotion of social interaction, the connectivity within the city for both vehicles and pedestrians, active engagement of the people with the space,
Ranmalsingha R. J. C. Jayakody +3 more
doaj +1 more source
Disability-aware adaptive and personalised learning for students with multiple disabilities [PDF]
Purpose The purpose of this paper is to address how virtual learning environments (VLEs) can be designed to include the needs of learners with multiple disabilities.
Brayshaw, Mike, Nganji, Julius T.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Background: The implementation of artificial intelligence (AI) has become a pivotal interdisciplinary challenge, creating new opportunities for sharing information, driving innovation, and transforming societal interactions with technology.
Matteo Zallio +2 more
doaj +1 more source

