Results 161 to 170 of about 13,585 (267)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Technical evaluation of language models adapted for the automation of legal contracts: clause extraction, classification, and summarization. [PDF]

Front Artif Intell
Govea J, Ortiz-Gárces I, Palacios P, Navarro AM, Del Pino SA, Villegas-Ch W.   +5 more
europepmc   +1 more source

Terahertz‐Nanoscale Visualization of the Microscopic Spin‐Charge Architecture of Colossal Magnetoresistive Switching

Advanced Science, EarlyView.
This study employs cryogenic magneto‐terahertz nanoscopy to reveal the real‐space electrodynamics of the colossal magnetoresistance transition. By capturing the terahertz electrodynamic evolution of field‐driven spin switching, the work unveils the dissipative dynamics of emergent metallic states, providing a high‐frequency view of coupled spin‐charge ...
Samuel Haeuser, Randall K. Chan, Richard H. J. Kim, Joong‐Mok Park, Martin Mootz, Thomas Koschny, Jigang Wang   +6 more
wiley   +1 more source

Prior Calf Strain as a Risk Factor for Achilles Tendon Rupture in National Basketball Association Players: A Retrospective Analysis. [PDF]

Orthop J Sports Med
Elsabbagh Z, Le Y, Bcharah G, Ryu D, Badin D, Hsu NN, Thompson JM, Aiyer A.   +7 more
europepmc   +1 more source

Incomplete Pharyngeal Contraction [PDF]

, 2020
openaire   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Governance Challenges of Smallholder Agricultural Carbon Projects and the Potential of Digital Tools: Insights from Kenya. [PDF]

Environ Manage
Mantey V, Birner R, Birkenberg A, Bosch C, Yameogo VG, Mburu J.   +5 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A Comprehensive and Unified Survey on Blockchain-Enabled SDN Cybersecurity: Industry Use Cases, Threat Landscapes, Defense Architectures, and Open Challenges. [PDF]

Sensors (Basel)
Dudukcu D, Gorgulu AB, Karakus M, Savran Kiziltepe R, Basbrain A.   +4 more
europepmc   +1 more source

Dicationic Ion‐Pair Doping Enables Stable and High‐Performing Conducting Polymers for Organic Thermoelectrics

Advanced Science, EarlyView.
TAB–2TFSI enables efficient ion‐pair doping across a wide range of conjugated polymers, where the strongly oxidizing TAB core drives charge transfer, and the TFSI counterions promote favorable ionic compensation. This dicationic dopant promotes uniform dopant distribution, improves structural order, and increases carrier delocalization, establishing a ...
Juhyung Park, Shubhradip Guchait, Tanmay Sinha, Cynthia Verduyckt, Vijitha Ignatious, Tzu‐Yi Yu, Heyi Xia, Altynay Kaidarova, Michael Ng, Siebe Detavernier, Martin Rosenthal, Maristella Alessio, Daniel Escudero, Guy Koeckelberghs, Francisco Molina‐Lopez   +14 more
wiley   +1 more source