Results 31 to 40 of about 171,919 (284)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

New Estimates on Hermite–Hadamard Type Inequalities via Generalized Tempered Fractional Integrals for Convex Functions with Applications

Fractal and Fractional, 2023
This paper presents a novel approach by introducing a set of operators known as the left and right generalized tempered fractional integral operators.
Artion Kashuri, Yahya Almalki, Ali M. Mahnashi, Soubhagya Kumar Sahoo   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

GENERATING FUNCTION FOR BERNOULLI NUMBERS AND ITS GENERALIZATIONS [PDF]

Journal of Mechanics of Continua and Mathematical Sciences
This paper explores certain generalizations of the generating function of Bernoulli numbers, the computation of integrals, and the investigation of the convergence of integrals from these functions.
Gasanov Magomedyusuf
doaj   +1 more source

Infinite Series and Logarithmic Integrals Associated to Differentiation with Respect to Parameters of the Whittaker M_κ,μ(x) Function I

Axioms, 2023
In this paper, first derivatives of the Whittaker function Mκ,μx are calculated with respect to the parameters. Using the confluent hypergeometric function, these derivarives can be expressed as infinite sums of quotients of the digamma and gamma ...
Alexander Apelblat, Juan Luis González-Santander   +1 more
doaj   +1 more source

Representation of Integral Dispersion Relations by Local Forms

, 2008
The representation of the usual integral dispersion relations (IDR) of scattering theory through series of derivatives of the amplitudes is discussed, extended, simplified, and confirmed as mathematical identities.
Ferreira, Erasmo, Sesma, Javier
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Theoretical Estimate of the Temperature Dependence of Electron Concentration and Lorenz Number in the Spherically Symmetric Zone of Semiconductors

Medžiagotyra, 2023
An accurate approach is proposed for the temperature dependence of electron concentration and Lorenz number in the spherically symmetric zone of semiconductors.
Mehriban EMEK
doaj   +1 more source