Results 31 to 40 of about 5,726,851 (263)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Non-Linear Matrix Completion for Social Image Tagging

IEEE Access, 2017
In this paper, we address the problem of social image tagging using practical vocabulary for mobile users on the social media. On the social media, images usually have an incomplete or noisy set of social tags provided by the mobile users, and we ...
Xing Xu, Li He, Huimin Lu, Atsushi Shimada, Rin-Ichiro Taniguchi   +4 more
doaj   +1 more source

Incomplete multi–view partial multi–label learning network with structure–aware consistent fusion

Journal of King Saud University: Computer and Information Sciences
In recent years, incomplete multi-view partial multi-label classification has attracted growing attention due to its practical relevance. However, many existing methods rely on equal-weight (average) fusion and thus overlook sample-wise reliability ...
Xingang Mao, Yang Xu, Wenbin Bu, Zherui Yang   +3 more
doaj   +1 more source

Research on Dimensional Reduction Methods for Incomplete Data Labeling Based on Maximal Consistent Blocks

Axioms
This paper proposes a unified approach based on maximal consistent blocks (MCBs) to address the problem of incomplete single-label and multi-label dimensional reduction.
Shiqi Chen, Zhongying Suo, Yuanbo Kong, Songlei Xue, Zhuoluo Wang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Weighted Ensemble Classification of Multi-label Data Streams

, 2017
Many real world applications involve classification of multilabel data streams. However, most existing classification models mostly focused on classifying single-label data streams.
Hong Shen, Hui Tian, Tian, H., Shen, Hong, Wang, Lulu, Tian, Hui, Shen, H., Wang, L., Lulu Wang   +8 more
core   +1 more source