A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Simultaneous endoscopic management of prostatic and seminal vesicle abscess using holmium laser enucleation of the prostate and seminal vesiculoscopy: a case series. [PDF]
Zhang G, Wang J, Lu W, Zhao R.
europepmc +1 more source
Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali +2 more
wiley +1 more source
A Generalizable Multimodal Model for Treatment-Stratified Risk and Survival Assessment under Real-World Constraints: A Multi-Center Study of Colorectal Cancer. [PDF]
Cao C +15 more
europepmc +1 more source
Anode‐Free Sodium Metal Batteries: From Materials Design to System‐Level Integration
Anode‐free sodium metal batteries hold no sodium reserve, so every inefficiency becomes permanent loss. Resolving the inventory into reversible, dead, and chemically bound fractions exposes what Coulombic efficiency hides. Practical 500‐cycle operation requires above 99.95%, a threshold few systems meet under lean electrolyte and high areal capacity ...
Hamid Hussain +10 more
wiley +1 more source
Computational prediction of TCR cross-reactivity: principles, challenges and translational opportunities. [PDF]
Li W +5 more
europepmc +1 more source
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang +18 more
wiley +1 more source
MDIFN: a deep learning-based multi-dimensional interaction fusion network for placental MRI segmentation. [PDF]
Wu Y, Lin Y, Zhou L, Zhan Y.
europepmc +1 more source
Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan +6 more
wiley +1 more source

