Results 181 to 190 of about 2,336,721 (286)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Structural and Electrochemical Analyses on the Transformation of CaFe2O4‑Type LiMn2O4 from Spinel-Type LiMn2O4

ACS Omega, 2019
Kazuhiko Mukai, Takeshi Uyama, Ikuya Yamada   +2 more
doaj   +1 more source

Creative problem-solving after experimentally provoking dreams of unsolved puzzles during REM sleep. [PDF]

Neurosci Conscious
Konkoly KR, Morris DJ, Hurka K, Martinez AM, Sanders KEG, Paller KA.   +5 more
europepmc   +1 more source

Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers

FEBS Open Bio, EarlyView.
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo, Emma Piccoli, Luca Bombardi, Martina Aulitto, Salvatore Fusco   +4 more
wiley   +1 more source

Integrating the Structure–Activity Relationship Matrix Method with Molecular Grid Maps and Activity Landscape Models for Medicinal Chemistry Applications

ACS Omega, 2019
Atsushi Yoshimori, Toru Tanoue, Jürgen Bajorath   +2 more
doaj   +1 more source

A cluster of acidic residues in the cytoplasmic domain of SARS-CoV-2 Spike is required for virion-incorporation and infectivity. [PDF]

PLoS One
Stoneham CA, Singh R, De Leon A, Tafelmeyer P, Acosta F, Fuori A, Anderson M, Ramirez PW, Schwartzer-Sperber HS, Pillai S, Lewinski MK, Guatelli J.   +11 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Widely-used boronic esters as synthetically-versatile directing groups for C-H activation and hydrogen isotope exchange. [PDF]

Chem Sci
Townsley JC, Smith C, Lindsay DM, Liwicki GM, Measom ND, Paterson LC, Kerr WJ.   +6 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Material-Mechanistic Interplay in SiCN Wafer Bonding for 3D Integration

ACS Omega
Hayato Kitagawa, Ryosuke Sato, Sodai Ebiko, Atsushi Nagata, Chiwoo Ahn, Yeounsoo Kim, Jiho Kang, Akira Uedono, Fumihiro Inoue   +8 more
doaj   +1 more source