Results 191 to 200 of about 2,336,721 (286)

DNA polymerase λ autoinhibition is relieved via Ku interaction during non-homologous end joining. [PDF]

Nucleic Acids Res
Case BC, Scoccia L, Zhao Z, Loparo JJ.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

RRM1 inhibition sensitizes lung adenocarcinoma to decitabine treatment. [PDF]

Cell Death Dis
Jiang N, Liu J, Vaghasia A, Anders N, Rudek M, Nelson WG, Yegnasubramanian S, Zhou J.   +7 more
europepmc   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells. [PDF]

Nat Commun
Kienle SM, Sigg M, Schneider T, Stuber K, Lehmann J, Jansen J, Stengel F, Marx A, Kovermann M, Scheffner M.   +9 more
europepmc   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Research on Mechanical Properties of Nano-Modified Foam Concrete Improved by Micro-inCorporated Carbon Nanotubes. [PDF]

Materials (Basel)
Zhang S, Jiang P, Wang H, Feng D, Wang H.   +4 more
europepmc   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Using mRNA and small RNA gene expression changes in peripheral blood for easy detection of Ra-223 incorporation

BIO Web of Conferences, 2019
Ostheim Patrick, Majewski Matthäus, Miederer Matthias, Schreckenberger Mathias, Nestler Tim, Hoffmann Manuela A., Port Matthias, Abend Michael   +7 more
doaj   +1 more source

Iso-pseudoprolines as versatile tools for late-stage peptide backbone modifications. [PDF]

Chem Sci
Milewska KD, Schwartz BD, Canning JR, Modak U, Attard FC, Gardiner MG, Van Raad D, Huber T, Malins LR.   +8 more
europepmc   +1 more source