ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai +13 more
wiley +1 more source
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye +11 more
wiley +1 more source
Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan +3 more
wiley +1 more source
Thermally Fine-Tuned NiO<sub>x</sub>-MAPbI<sub>3</sub> Interfaces Enabled by a Polymeric Surface Additive for High-Sensitivity Self-Powered Photodetectors. [PDF]
Jeong H, Lee K, Kim W, Park B.
europepmc +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Membrane Molecular Species Remodeling as a Signature of ω-3 Fatty Acid Action in Cultured Neural Cells. [PDF]
Nicholas KR +8 more
europepmc +1 more source
Simple and Scalable Electrochemical Reduction of Alkyl Oxalates Using Carbon-Based Electrodes. [PDF]
Kissel S +3 more
europepmc +1 more source
Straw type governs methane-cycling microbiomes and CH<sub>4</sub> emissions in paddy soils via abiotic and biotic interactions. [PDF]
Wang Y, Zhang Y, Ji Y, Feng Y, Feng Z.
europepmc +1 more source
Sulfur-Stabilized High Entropy Oxysulfides Enable Efficient CC Bond Cleavage in Ethylene Glycol Electrooxidation for Sustainable Plastic Upcycling to Formate. [PDF]
Bolar S +6 more
europepmc +1 more source

