Results 101 to 110 of about 199,658 (311)
The Lancet Global Health, 2015 Background: In 2012, WHO changed its recommendation for intermittent preventive treatment of malaria during pregnancy (IPTp) from two doses to monthly doses of sulfadoxine-pyrimethamine during the second and third trimesters, but noted the importance of ...
Silke Fernandes, MSc +10 more
doaj +1 more source
Advanced Sustainable Systems, EarlyView.This study highlights the activation mechanism for calcium storage in NASICON‐NaV2(PO4)3, showcasing it as an effective cathode for calcium‐ion batteries at room temperature. It delivers a discharge capacity of 106.9 mAh g−1 (82% improvement) at ≈3.5 V (vs Ca/Ca2+), with good cyclability, offering insights for developing high‐performance cathodes for ...
Hyungjin Lee +5 more
wiley +1 more source
Health Economics ReviewBackground Clinical trials have demonstrated the efficacy of edaravone dexborneol in the treatment of acute ischemic stroke. This study aims to determine the cost-effectiveness of edaravone dexborneol compared with human urinary kallidinogenase from ...
Pingyu Chen +5 more
doaj +1 more source
Solving Problems of Imperfect Data Streams by Incremental Decision Trees
Journal of Emerging Technologies in Web Intelligence, 2013 Big data is a popular topic that attracts highly attentions of researchers from all over the world. How to mine valuable information from such huge volumes of data remains an open problem. Although fast development of hardware is capable of handling much larger volume of data than ever before, in the author’s opinion, a well-designed algorithm is ...
openaire +2 more sources
Advanced Science, EarlyView.Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma +10 more
wiley +1 more source
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases
Advanced Science, EarlyView.Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang +13 more
wiley +1 more source
Advanced Science, EarlyView.Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo +7 more
wiley +1 more source
Advanced Science, EarlyView.Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao +16 more
wiley +1 more source
Human Vaccines & ImmunotherapeuticsChinese authority approved nirsevimab to prevent respiratory syncytial virus (RSV) in January 2024. We aimed to assess the cost-effectiveness of nirsevimab immunization among infants in Shanghai.
Qiang Wang +10 more
doaj +1 more source