Results 41 to 50 of about 24,292,656 (284)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Assessing Seismic Risk in Sagaing City: A Case Study of Incremental Dynamic and Pushover Analyses on Multi-Span Reinforced Concrete Bridge Pier

Civil and Environmental Engineering
Sagaing City, situated along the highly active Sagaing Fault, faces significant seismic hazards, necessitating rigorous evaluation of its critical infrastructure. This study explores the seismic performance of a multi-span reinforced concrete bridge pier
Htay Khin Thuzar, Masrilayanti Masrilayanti, Tanjung Jafril, Olivia Monita   +3 more
doaj   +1 more source

A Proposed Fragility Curve Based on PO-ID Hybrid Analysis for Seismic Assessment Performance of the Reinforced Concrete Continuous Bridges in Earthquake Prone Area

Buildings
In earthquake-prone regions, the seismic performance assessment of reinforced concrete (RC) continuous bridges is critical for ensuring their resilience and safety.
Khin Thuzar Htay, Jafril Tanjung, Masrilayanti, Monita Olivia, Fadzli Mohamed Nazri, Mulyadi Bur   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

opseestools: A Python library to streamline OpenSeesPy workflows

SoftwareX
OpenSees, a framework for nonlinear structural analysis, has significantly advanced seismic research and practice. The introduction of OpenSeesPy in 2018, which integrated Python as an interpreter alongside TCL, greatly enhanced the framework's utility ...
Orlando Arroyo, Dirsa Feliciano, Daniela Novoa, Jairo Valcárcel   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Fragility analysis of bridge structures: a global perspective & critical review of past & present trends

Advances in Bridge Engineering, 2023
Bridges are vital to modern transportation infrastructure, providing convenient and efficient access to different locations. However, these structures are susceptible to forces that can cause significant damage and pose a hazard in the event of seismic ...
Kanan Thakkar, Anshum Rana, Harsh Goyal
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Population-based incremental learning with memory scheme for changing environments [PDF]

, 2005
Copyright @ 2005 ACMIn recent years there has been a growing interest in studying evolutionary algorithms for dynamic optimization problems due to its importance in real world applications.
Yang, S, Shengxiang Yang, Yang, Shengxiang   +2 more
core   +1 more source