Results 41 to 50 of about 221,721 (309)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

An investigation of multi-pass incremental sheet forming [PDF]

MATEC Web of Conferences
This study investigates toolpath strategies of multi-pass incremental sheet forming (MSPIF) including a combination of an IN (I) pass where the tool moves inwards and downwards and an OUT (O) pass where the tool moves outward and upward. MSPIF processes (
Ridland Matthew, Waldram Lawrence, Qin Zhenyuan, Peng Wenxuan, Ou Hengan   +4 more
doaj   +1 more source

A Comparative Investigation of Conventional and Hammering-Assisted Incremental Sheet Forming Processes for AA1050 H14 Sheets

Metals, 2021
Incremental Sheet Forming (ISF) is emerging as one of the popular dieless forming processes for the small-sized batch production of sheet metal components. However, the parts formed by the ISF process suffer from poor surface finish, geometric inaccuracy,
Harshal Y. Shahare, Abhay Kumar Dubey, Pavan Kumar, Hailiang Yu, Alexander Pesin, Denis Pustovoytov, Puneet Tandon   +6 more
doaj   +1 more source

A study of incremental sheet forming by using water jet [PDF]

, 2017
In this work, a variant of the incremental sheet forming (ISF) process, namely the incremental sheet forming by using water jet (ISF-WJ), was studied. In the investigation, an ISF-WJ prototype machine was designed and developed. Different design concepts
B Jurisevic, B Jurisevic, B Lu, B Lu, B. Lu, BT Araghi, H Iseki, H Iseki, H. Long, H. Ou, J Jeswiet, J. Chen, J. F. Cao, M. W. Mohamed Bazeer, Q Zhang, R Malhotra, S Matsubara, S. Ai, V Sajn, WC Emmens, WC Emmens   +20 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Properties of Components with Incrementally Formed Gears

Metals, 2019
The process class of sheet-bulk metal forming (SBMF) involves several advantages for the manufacture of functional components. Its incremental variant (iSBMF) enables a very flexible dimensioning of components. To treat the unfavorable manufacturing time
Sebastian Wernicke, Peter Sieczkarek, Soeren Gies, A. Erman Tekkaya   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Cold stress in captive great apes recorded in incremental lines of dental cementum [PDF]

, 2002
Incremental lines in dental cementum of museum specimens of 11 free-ranging great apes were compared to the respective structures in 5 captive specimens of known age-at-death, and with many known life-history parameters.
Cipriano, Alessandra
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Numerical study on the thickness homogenization in hole-flanging by single-point incremental forming [PDF]

, 2018
Incremental sheet forming is a novel technology that has significant benefits compared to conventional forming. However, it is a time-consuming process that is usually carried out in several forming stages to homogenize deformation and avoid material ...
Borrego Puche, Marcos, Centeno Báez, Gabriel, López Fernández, José Andrés, Martínez Donaire, Andrés Jesús, Morales-Palma, Domingo, Vallellano Martín, Carpóforo   +5 more
core   +1 more source