Results 251 to 260 of about 440,724 (260)

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

open access: yesAdvanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang   +15 more
wiley   +1 more source

Polymorphism Crystal Structure Prediction with Adaptive Space Group Diversity Control

open access: yesAdvanced Science, EarlyView.
Polymorphic materials exhibit diverse properties despite identical compositions, but predicting their crystal structures remains challenging. This study introduces ParetoCSP2, a multi‐objective genetic algorithm incorporating genotypic age, energy, and space group diversity.
Sadman Sadeed Omee   +3 more
wiley   +1 more source

Multiscale Design of Dental Restorative Materials: Mechanistic Foundations, Technological Innovations, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
From conventional ceramics to bioinspired smart composites, this review charts the evolution of dental restorative biomaterials. Integrating materials innovation, advanced manufacturing technologies, and bioinspired strategies, it presents a roadmap for developing functional, clinically translatable restorations that combine durability, adaptability ...
Bailei Li   +14 more
wiley   +1 more source

Rapid Arbitrary‐Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment

open access: yesAdvanced Science, EarlyView.
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao   +17 more
wiley   +1 more source

Super Time‐Resolved Tomography

open access: yesAdvanced Science, EarlyView.
A super time‐resolved tomography (STRT) approach is presented to reconstruct 4D X‐ray movies with an order‐of‐magnitude improvement in temporal resolution without sacrificing spatial resolution. By leveraging a physics‐informed deep learning algorithm that shares spatiotemporal features, STRT achieves high‐fidelity 3D reconstructions from sparse‐view ...
Zhe Hu   +6 more
wiley   +1 more source

An Active, Multimodal Neural Interface for Real‐Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics

open access: yesAdvanced Science, EarlyView.
A chronically implantable neural interface enables real‐time multimodal monitoring of electrical, thermal, and photodynamic activities. Incorporating silicon‐based transistor arrays with a functional multiplexing strategy and resistive sensors, the device delivers high‐fidelity recordings with long‐term stability and biocompatibility.
Jiahao Li   +18 more
wiley   +1 more source

Towards Effective Open-set Graph Class-incremental Learning

open access: gold
Jiazhen Chen   +5 more
openalex   +1 more source

Multi‐Level Optical Physical Unclonable Function Based on Random Surface Scattering for Hierarchical Cryptographic Protocols

open access: yesAdvanced Science, EarlyView.
This study proposed physical unclonable function based multi‐level key space generation scheme. By exploiting speckle characteristic, a size‐controllable structure is achieved and that is suitable foundation for multiple key extraction. The flexible key space supports various specifications for advanced applications, such as hierarchical authentication
Jeong Jin Kim, Min Seong Kim, Gil Ju Lee
wiley   +1 more source

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