Results 181 to 190 of about 300,807 (294)

Quantitative Stain Mapping in X‐Ray Virtual Histology

open access: yesAdvanced Science, EarlyView.
Virtual histology promises 3D tissue examination without physical sectioning, yet has lacked the tissue‐specificity of conventional pathology. This work demonstrates the first quantitative three‐dimensional stain mapping at histologically relevant resolution, separating contrast agent from tissue to reveal cellular features such as nuclei. The approach
Dominik John   +16 more
wiley   +1 more source

Incremental Validity of Montreal Cognitive Assessment Index Scores in Mild Cognitive Impairment and Alzheimer Disease. [PDF]

open access: yesDement Geriatr Cogn Disord, 2018
Goldstein FC   +3 more
europepmc   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

open access: yesAdvanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos   +6 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

open access: yesAdvanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou   +19 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

open access: yesAdvanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang   +13 more
wiley   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

open access: yesAdvanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang   +5 more
wiley   +1 more source

Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials

open access: yesAdvanced Science, EarlyView.
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan   +8 more
wiley   +1 more source

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