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Thiazides for kidney stone recurrence prevention. [PDF]

open access: yesCurr Opin Nephrol Hypertens
Bargagli M   +3 more
europepmc   +1 more source
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Pharmacokinetics of Indapamide in Dogs

Journal of Pharmaceutical Sciences, 1981
Four beagle dogs received both an oral and intravenous dose (1 mg/kg) of indapamide in a crossover design. The blood levels and urinary excretion of intact indapamide were measured, and the pharmacokinetic parameters of the drug were defined. The results indicate that indapamide is completely bioavailable after an oral dose and does not undergo first ...
Jo A. Treitman, Peter E. Grebow
openaire   +3 more sources

Photolytic Decomposition of Indapamide

Journal of Pharmaceutical Sciences, 1979
Photolytic decomposition of indapamide (I) in nitrogen-flushed methanol yields 3-sulfamoyl-4-chlorobenzamide (II), 2-methylindoline (III), semicarbazide (IV), and 1-(N-formamido)-2-methylindoline (V); in oxygen-flushed methanol, II--V, 1-aminocarboxymethyl-2-methylindoline (VI), 3-sulfamoyl-4-chlorobenzoic acid (VII), methyl-3-sulfamoyl-4 ...
Albert R. Taylor   +2 more
openaire   +3 more sources

Indapamide in the Diabetic Hypertensive

Archives of Internal Medicine, 1988
To the Editor. —We read with interest the article by Osei et al 1 in the October 1986 issue of theArchives. The authors performed an open study on 13 hypertensive diabetic patients to assess the effects of a 24-week administration of indapamide on blood pressure, glucose, and lipid metabolism.
François Brackman, David Guez
openaire   +3 more sources

Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine

European Journal of Pharmacology, 1994
5-OH-Indapamide is a principal metabolite of indapamide, and possesses similar antihypertensive and diuretic properties. This study investigated the mechanisms of the acute vasodilator actions of 5-OH-indapamide, indapamide, hydrochlorothiazide and cicletanine and their interaction with ion channels in isolated guinea pig mesenteric arteries ...
Michael Schachter   +2 more
openaire   +3 more sources

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