Results 91 to 100 of about 105,918 (288)

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

Development of a technique for molecular typing of Bacillus anthracis strains using new VNTR and INDEL markers

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Bacillus anthracis, the pathogen of a particularly dangerous zoonotic disease known as anthrax, requires strict epidemiological control and is characterized by high genetic homogeneity, which necessitates the development of genotyping ...
Grigorii A. Pechkovskii, Evgeny I. Eremenko, Alla G. Ryazanova, Sergey V. Pisarenko, Nikolay A. Shapakov, Lyudmila Yu. Aksenova, Olga V. Semenova, Lyudmila D. Timchenko, Alexander N. Kulichenko   +8 more
doaj   +1 more source

Kevlar: A Mapping-Free Framework for Accurate Discovery of De Novo Variants. [PDF]

, 2019
De novo genetic variants are an important source of causative variation in complex genetic disorders. Many methods for variant discovery rely on mapping reads to a reference genome, detecting numerous inherited variants irrelevant to the phenotype of ...
Brown, C Titus, Hormozdiari, Fereydoun, Standage, Daniel S   +2 more
core   +1 more source

Identifying Structural Variation in Haploid Microbial Genomes from Short-Read Resequencing Data Using Breseq [PDF]

, 2014
Mutations that alter chromosomal structure play critical roles in evolution and disease, including in the origin of new lifestyles and pathogenic traits in microbes.
Barrick, Jeffrey E., Borges, Jordan J., Colburn, Geoffrey, Deatherage, Daniel E., Knoester, David B., Meyer, Austin G., Reba, Aaron, Strand, Matthew D., Traverse, Charles C.   +8 more
core   +1 more source

DNA Sequence variability analysis of the gD and the UL36 genes of Bovine herpesvirus-1 isolated from field cases in Indonesia

Journal of Applied Animal Research, 2019
To investigate the genotype of Bovine herpesvirus-1 (BHV-1) isolated in Indonesia (n = 10), the DNA sequences of fragments of two genes, including the middle third of the gD gene and the downstream end of UL36, were determined using nested PCR.
Hidayati Dewi Noor, Untari Tri, Wibowo Michael Haryadi, Asmara Widya, Akiyama Koichi   +4 more
doaj   +1 more source

Cas9-induced large deletions and small indels are controlled in a convergent fashion [PDF]

, 2022
Michael Kosicki, Felicity Allen, Frances Steward, Kärt Tomberg, Yangyang Pan, Allan Bradley   +5 more
openalex   +1 more source

SMaSH: A Benchmarking Toolkit for Human Genome Variant Calling

, 2014
Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call variants from human
Bresler, Ma'ayan, Curtis, Kristal, Hartl, Christopher, Jordan, Michael I., Liptrap, Jesse, Newcomb, Julie, Patterson, David, Song, Yun S., Talwalkar, Ameet, Terhorst, Jonathan   +9 more
core   +1 more source

Genome-Wide SNP and Indel Discovery in Abaca (Musa textilis Née) and among Other Musa spp. for Abaca Genetic Resources Management [PDF]

, 2023
Cris Francis C. Barbosa, Jayson C. Asunto, Rhosener Bhea L. Koh, Daisy May C. Santos, Dapeng Zhang, Ernelea P. Cao, Leny C. Galvez   +6 more
openalex   +1 more source

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

bioRxiv, 2019
Ancestral sequence reconstruction is a technique that is gaining widespread use in molecular evolution studies and protein engineering. Accurate reconstruction requires the ability to handle appropriately large numbers of sequences, as well as insertion ...
G. Foley, Ariane Mora, Connie M. Ross, Scott Bottoms, Leander Sützl, Marnie L. Lamprecht, J. Zaugg, Alexandra Essebier, Brad Balderson, Rhys Newell, Raine E. S. Thomson, B. Kobe, R. Barnard, L. Guddat, G. Schenk, Jörg Carsten, Y. Gumulya, B. Rost, D. Haltrich, V. Sieber, E. Gillam, M. Bodén   +21 more
semanticscholar   +1 more source

Chloroplast Genome-Based Hypervariable Markers for Rapid Authentication of Six KoreanPyropia Species

Diversity, 2019
We previously established that polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis using partial plastid rbcL and mitochondrial trnC−trnP gene sequences can be used to distinguish the six representative Pyropia ...
Sung-Je Choi, Yonguk Kim, Chulyung Choi
doaj   +1 more source